Xinyi Y. Zhou

TL;DR: In vivo results are presented showing that an emerging imaging modality, magnetic particle imaging (MPI), can be combined with magnetic hyperthermia into an image-guided theranostic platform, and quantitative MPI image guidance for treatment planning and use of the MPI gradients for spatial localization of magnetichyperthermia to arbitrarily selected regions.

TL;DR: The use of MPI along with long-circulating, PEG-stabilized SPIOs for rapid in vivo detection and quantification of GI bleed is demonstrated and clinical translation of the technique is achievable.

TL;DR: A new diagnostic imaging modality called magnetic particle imaging is introduced that allows for a focused theranostic approach encompassing treatment planning, treatment monitoring and spatially localized inductive heating in magnetic fluid hyperthermia.

TL;DR: The first high-contrast in vivo MPI lung perfusion images of rats are shown using a novel lung perfusions agent, MAA-SPIOs, enabling deep imaging of anatomy including within the lungs, which is very challenging with MRI.

TL;DR: It is demonstrated that superparamagnetic iron oxide nanoparticles (SPIONs) can be used to label and track aerosols in vivo with high sensitivity using an emerging medical imaging technique known as magnetic particle imaging (MPI).