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Xiong Xie
Researcher at Chinese Academy of Sciences
Publications - 11
Citations - 1121
Xiong Xie is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 7 publications receiving 641 citations.
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Journal ArticleDOI
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Wenhao Dai,Wenhao Dai,Bing Zhang,Xia Ming Jiang,Haixia Su,Jian Li,Jian Li,Yao Zhao,Xiong Xie,Zhenming Jin,Jingjing Peng,Fengjiang Liu,Chunpu Li,You Li,Fang Bai,Haofeng Wang,Xi Cheng,Xiaobo Cen,Shulei Hu,Xiuna Yang,Jiang Wang,Xiang Liu,Gengfu Xiao,Hualiang Jiang,Zihe Rao,Lei Ke Zhang,Yechun Xu,Haitao Yang,Hong Liu +28 more
TL;DR: Two peptidomimetic aldehydes were designed, synthesized, and evaluated as antiviral drug candidates, and both exhibited excellent inhibitory activity and potent anti-SARS-CoV-2 infection activity.
Posted ContentDOI
Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease
Wenhao Dai,Wenhao Dai,Bing Zhang,Xiaming Jiang,Haixia Su,Jian Li,Yao Zhao,Xiong Xie,Zhenming Jin,Jingjing Peng,Fengjiang Liu,Chunpu Li,You Li,Fang Bai,Haofeng Wang,Xi Cheng,Xiaobo Cen,Shulei Hu,Xiuna Yang,Jiang Wang,Xiang Liu,Gengfu Xiao,Hualiang Jiang,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Leike Zhang,Yechun Xu,Haitao Yang,Hong Liu,Hong Liu,Hong Liu +31 more
TL;DR: In an effort to rapidly discover lead compounds targeting Mpro, two compounds were designed and synthesized, both of which exhibited excellent inhibitory activity and showed good PK properties in vivo, and 11a exhibited low toxicity which is promising drug leads with clinical potential that merits further studies.
Journal ArticleDOI
Ir(iii)-Catalyzed direct C-H functionalization of N-phenylacetamide with α-diazo quinones: a novel strategy for producing 2-hydroxy-2'-amino-1,2'-biaryl scaffolds.
Xingjun Li,Jiang Wang,Xiong Xie,Wenhao Dai,Wenhao Dai,Xu Han,Kaixian Chen,Kaixian Chen,Hong Liu,Hong Liu +9 more
TL;DR: α-Diazo quinones were applied in an Ir(iii)-catalyzed direct C-H functionalization assisted by N-phenylacetamide for the construction of highly functionalized 2-hydroxy-2'-amino-1,1'-biaryl scaffolds in good to excellent yields.
Journal ArticleDOI
Synthesis of Pyrazolo[1,2‐a]cinnolines via Rhodium(III)‐Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides
Shulei Hu,Shulei Hu,Xu Han,Xiong Xie,Feifei Fang,Feifei Fang,Yong Wang,Abdusaid Saidahmatov,Hong Liu,Hong Liu,Jiang Wang +10 more
Journal ArticleDOI
Synthesis of Highly Fused Pyrano[2,3-b]pyridines via Rh(III)-Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature.
TL;DR: A facile access to the polycyclic fused pyrano[2,3-b]pyridines has been established under room temperature via Rh(III)-catalyzed C-H bond activation and intramolecular cascade annulation and this strategy can be extended to the late-stage functionalization of drugs possessing CN group.