J
Jingjing Peng
Researcher at Chinese Academy of Sciences
Publications - 7
Citations - 1137
Jingjing Peng is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Protease & Docking (molecular). The author has an hindex of 4, co-authored 7 publications receiving 655 citations.
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Journal ArticleDOI
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Wenhao Dai,Wenhao Dai,Bing Zhang,Xia Ming Jiang,Haixia Su,Jian Li,Jian Li,Yao Zhao,Xiong Xie,Zhenming Jin,Jingjing Peng,Fengjiang Liu,Chunpu Li,You Li,Fang Bai,Haofeng Wang,Xi Cheng,Xiaobo Cen,Shulei Hu,Xiuna Yang,Jiang Wang,Xiang Liu,Gengfu Xiao,Hualiang Jiang,Zihe Rao,Lei Ke Zhang,Yechun Xu,Haitao Yang,Hong Liu +28 more
TL;DR: Two peptidomimetic aldehydes were designed, synthesized, and evaluated as antiviral drug candidates, and both exhibited excellent inhibitory activity and potent anti-SARS-CoV-2 infection activity.
Journal ArticleDOI
Rhodium(III)-Catalyzed C-H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides.
TL;DR: A synthetic route of decorating maleimide on peptides is provided, providing a high tolerance of functional groups and protecting groups, and this method was applied to prepare peptide conjugation with molecules such as drugs and fluorescence probes.
Journal ArticleDOI
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.
Wenhao Dai,Dirk Jochmans,Hang Xie,Hang Yang,Jian Li,Jian Li,Haixia Su,Di Chang,Jiang Wang,Jingjing Peng,Lili Zhu,Yong Nian,Yong Nian,Rolf Hilgenfeld,Hualiang Jiang,Kaixian Chen,Leike Zhang,Yechun Xu,Johan Neyts,Hong Liu +19 more
TL;DR: A series of peptidomimetic aldehydes was designed and synthesized to target 3C protease (3Cpro) of enterovirus 71 (EV71) as mentioned in this paper.
Posted ContentDOI
Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease
Wenhao Dai,Wenhao Dai,Bing Zhang,Xiaming Jiang,Haixia Su,Jian Li,Yao Zhao,Xiong Xie,Zhenming Jin,Jingjing Peng,Fengjiang Liu,Chunpu Li,You Li,Fang Bai,Haofeng Wang,Xi Cheng,Xiaobo Cen,Shulei Hu,Xiuna Yang,Jiang Wang,Xiang Liu,Gengfu Xiao,Hualiang Jiang,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Leike Zhang,Yechun Xu,Haitao Yang,Hong Liu,Hong Liu,Hong Liu +31 more
TL;DR: In an effort to rapidly discover lead compounds targeting Mpro, two compounds were designed and synthesized, both of which exhibited excellent inhibitory activity and showed good PK properties in vivo, and 11a exhibited low toxicity which is promising drug leads with clinical potential that merits further studies.
Journal ArticleDOI
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists.
Jingjing Peng,Lifen Zhao,Lanlan Wang,Hui Chen,Yunguang Qiu,Jiang Wang,Huaiyu Yang,Jun Liu,Hong Liu +8 more
TL;DR: A novel series of 2-(phenoxyaryl)-3-urea derivatives were designed, synthesized, and biologically evaluated for their anti-thrombotic activity, and compound 13 interacted well with Phe119 through hydrophobic interaction and modestly improved the P2Y1 receptor antagonistic activity, making it justifiable for further investigation.