Xu-Dong Zhao

TL;DR: Results indicate that SERT might treat depression by inhibiting the activation of microglia via the NF-κB signaling pathway and provides a basis for the research and development of antidepressants that act to reduce inflammation and the expression of inflammatory mediators.

TL;DR: It is demonstrated that arctiin ameliorates depression by inhibiting the activation of microglia and inflammation via the HMGB1/TLR4 and TNF-α/TNFR1 signaling pathways.

TL;DR: The effects and underlying molecular mechanisms of AG against depressive behaviors induced by T. gondii infection were elucidated, including attenuated microglial activation and neuroinflammation via the Toll-like receptor/nuclear factor-kappa B and tumor necrosis factor receptor 1/NF-κB signaling pathways.

TL;DR: It is demonstrated that AG exhibited prominent hepatoprotective activities in toxoplasmic liver injury with anti-inflammatory effects by inhibiting the HMGB1/TLR4/NF-κB signaling axis, which provides the basis for the development of new drugs to treat toxoplasmsic hepatitis.

TL;DR: This review focuses on recent publications investigating vertical transmission of T. gondii infection, cellular immunopathogenesis and protective immunity in primary toxoplasmosis during pregnancy.