Guang Hua Xu

TL;DR: It is suggested that imperatorin is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity.

TL;DR: The anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice were demonstrated and it was proved that art Artemisinin potentiated TNF-α-induced apoptosis.

TL;DR: Investigation of the potential activity of panaxadiol on programmed cell death-ligand 1 (PD-L1) expression and tumour proliferation in human colon cancer cells and the underlying mechanism revealed insights into development of cancer therapeutic through PD-L 1 inhibition.

TL;DR: The result of the current study show that convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/ STAT3 (S727) signaling pathways in colorectal cancer cells and indicate that conv allatoxin could be a valuable candidate for the development of coloreCTal cancer therapeutic.

TL;DR: Results illustrated that curcumol inhibits the expression of PD-L1 through crosstalk between HIF-1α and p-STAT3 (T705) signaling pathways in hepatic cancer, and might represent a promising lead compound for the development of new targeted anti-cancer therapeutics.