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Xu Wang
Researcher at University of Texas Southwestern Medical Center
Publications - 18
Citations - 303
Xu Wang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Micelle. The author has an hindex of 6, co-authored 13 publications receiving 106 citations. Previous affiliations of Xu Wang include University of Science and Technology of China.
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Journal ArticleDOI
Prolonged activation of innate immune pathways by a polyvalent STING agonist
Suxin Li,Min Luo,Zhaohui Wang,Qiang Feng,Jonathan Wilhelm,Xu Wang,Li Wei,Jian Wang,Agnieszka Cholka,Yang Xin Fu,Baran D. Sumer,Hongtao Yu,Hongtao Yu,Jinming Gao +13 more
TL;DR: In this article, a polyvalent STING agonist, a pH-sensitive polymer bearing a seven-membered ring with a tertiary amine (PC7A), was shown to stimulate the production of pro-inflammatory cytokines by binding to a noncompetitive STING surface site.
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Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window.
Xu Wang,Jonathan Wilhelm,Li Wei,Suxin Li,Zhaohui Wang,Gang Huang,Jian Wang,Houliang Tang,Sina Khorsandi,Zhichen Sun,Bret M. Evers,Jinming Gao +11 more
TL;DR: A series of degradable ultra-pH sensitive (dUPS) polymers that amplify small acidic pH changes to efficacious therapeutic outputs are reported that open up opportunities in pH-targeted drug and protein therapy.
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Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer.
TL;DR: The interplay between these targets and breast cancer is reviewed, the progress of current research on small molecule inhibitors of these anti-breast cancer targets is summarized, and the structural and theoretical basis for designing novel anti-Breast cancer agents is provided.
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Comparative Study of Solution Properties of Amphiphilic 8-Shaped Cyclic-(Polystyrene-b-Poly(acrylic acid))2 and Its Linear Precursor
TL;DR: In this paper, an amphiphilic 8-shaped cyclic-(polystyrene-b-poly(acrylic acid))2 with two rings and its linear precursor was successfully prepared by a combination of atom transfer radical polymerization (ATRP) and click chemistry.
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Degradation Kinetics of Model Hyperbranched Chains with Uniform Subchains and Controlled Locations of Cleavable Disulfide Linkages
TL;DR: In this paper, a tetra-functional initiator with one alkyne, one disulfide linkage, and two bromine groups was used to make model hyperbranched structure with uniform subchains and controlled locations of cleavable linkages.