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Xudong Zhang
Researcher at University of California, Los Angeles
Publications - 80
Citations - 6796
Xudong Zhang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Computer science & Drug delivery. The author has an hindex of 33, co-authored 55 publications receiving 4629 citations. Previous affiliations of Xudong Zhang include Sun Yat-sen University & University of Southern California.
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Journal ArticleDOI
Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics.
Wei Tao,Xianbing Zhu,Xinghua Yu,Xiaowei Zeng,Quanlan Xiao,Xudong Zhang,Xiaoyuan Ji,Xusheng Wang,Jinjun Shi,Han Zhang,Lin Mei +10 more
TL;DR: A triple-response combined therapy strategy is achieved by PEGylated BP nanosheets, showing a promising and enhanced antitumor effect.
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In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
Qian Chen,Qian Chen,Chao Wang,Xudong Zhang,Guojun Chen,Quanyin Hu,Quanyin Hu,Hongjun Li,Jinqiang Wang,Di Wen,Yuqi Zhang,Yifei Lu,Yifei Lu,Guang Yang,Chen Jiang,Jun Wang,Gianpietro Dotti,Zhen Gu +17 more
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread.
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In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy.
Chao Wang,Jinqiang Wang,Xudong Zhang,Shuangjiang Yu,Di Wen,Quanyin Hu,Yanqi Ye,Hunter N. Bomba,Xiuli Hu,Zhuang Liu,Gianpietro Dotti,Zhen Gu +11 more
TL;DR: A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity and promotes an immune-mediated tumor regression in the tumor-bearing mice, with prevention of tumor recurrence after primary resection.
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Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
Zhongyuan Wang,Yanping Wu,Haifeng Wang,Yangqing Zhang,Lin Mei,Xuexun Fang,Xudong Zhang,Fang Zhang,Hongbo Chen,Ying Liu,Yuyang Jiang,Shengnan Sun,Yi Zheng,Na Li,Laiqiang Huang +14 more
TL;DR: In vitro and in vivo findings identify a mechanism regulating R HAMM expression and cancer metastasis wherein RHAMM is a downstream effector of mevalonate/Hippo pathways, and a YAP/TEAD-transcription and simvastatin-inhibition target, revealing interesting interplay of the pathways and potential targets for cancer therapeutic agents.
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A melanin-mediated cancer immunotherapy patch
Yanqi Ye,Chao Wang,Xudong Zhang,Quanyin Hu,Yuqi Zhang,Qi Liu,Di Wen,Joshua Milligan,Adriano Bellotti,Leaf Huang,Gianpietro Dotti,Zhen Gu +11 more
TL;DR: It is found that the spatiotemporal photoresponsive immunotherapy increases infiltration of polarized T cells and local cytokine release in mice after tumor challenge and elicited antitumor effects toward established primary tumor and distant tumor.