J
Jinqiang Wang
Researcher at University of California, Los Angeles
Publications - 84
Citations - 8114
Jinqiang Wang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Insulin & Drug delivery. The author has an hindex of 34, co-authored 69 publications receiving 5089 citations. Previous affiliations of Jinqiang Wang include University of North Carolina at Chapel Hill & Zhejiang University.
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Journal ArticleDOI
In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
Qian Chen,Qian Chen,Chao Wang,Xudong Zhang,Guojun Chen,Quanyin Hu,Quanyin Hu,Hongjun Li,Jinqiang Wang,Di Wen,Yuqi Zhang,Yifei Lu,Yifei Lu,Guang Yang,Chen Jiang,Jun Wang,Gianpietro Dotti,Zhen Gu +17 more
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread.
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The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment
Jinqiang Wang,Weiwei Mao,Lye Lin Lock,Jianbin Tang,Meihua Sui,Weilin Sun,Honggang Cui,Dong Xu,Youqing Shen +8 more
TL;DR: The micelle's blood circulation time and tumor accumulation increased with the increase in their diameters, with optimal diameter range of 100 to 160 nm, but the much higher tumor accumulation of the large micelles did not result in significantly improved therapeutic efficacy, because the large mouselles had poorer tumor penetration than the small ones.
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Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery.
Youqing Shen,Erlei Jin,Bo Zhang,Caitlin J. Murphy,Meihua Sui,Jian Zhao,Jinqiang Wang,Jianbin Tang,Maohong Fan,Edward A. Van Kirk,William J. Murdoch +10 more
TL;DR: The concept directly using drugs as part of a carrier is applicable to fabricating other highly efficient nanocarriers with a substantially reduced use of inert carrier materials and increased drug loading content without premature burst release.
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Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species.
Ping'an Ma,Haihua Xiao,Chang Yu,Jianhua Liu,Ziyong Cheng,Haiqin Song,Xinyang Zhang,Chunxia Li,Jinqiang Wang,Zhen Gu,Jun Lin +10 more
TL;DR: Tumor site-specific conversion of ROS generation induced by released cisplatin and Fe2+/Fe3+ from iron-oxide nanocarriers with cisPlatin(IV) prodrugs for enhanced anticancer activity but minimized systemic toxicity is demonstrated.
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Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
Quan Zhou,Shiqun Shao,Jinqiang Wang,Changhuo Xu,Jiajia Xiang,Ying Piao,Zhuxian Zhou,Qingsong Yu,Jianbin Tang,Xiangrui Liu,Zhihua Gan,Ran Mo,Zhen Gu,Youqing Shen +13 more
TL;DR: The conjugate showed a potent antitumour activity in mouse models that led to the eradication of small solid tumours and regression of large established tumours with clinically relevant sizes, and significantly extended the survival of orthotopic pancreatic tumour-bearing mice compared to that with the first-line chemotherapeutic drug gemcitabine.