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Xulin Jiang
Researcher at Wuhan University
Publications - 101
Citations - 3463
Xulin Jiang is an academic researcher from Wuhan University. The author has contributed to research in topics: Self-healing hydrogels & Gene delivery. The author has an hindex of 30, co-authored 85 publications receiving 2883 citations. Previous affiliations of Xulin Jiang include University of Birmingham & University of Amsterdam.
Papers
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Journal ArticleDOI
Novel bioreducible poly(amido amine)s for highly efficient gene delivery.
TL;DR: XTT assays showed that SS-PAAs and their polyplexes possess essentially no or only very low cytotoxicity at concentrations where the highest transfection activity is observed, indicating that bioreducible poly(amido amine)s have excellent properties for the development of highly potent and nontoxic polymeric gene carriers
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Degradable-brushed pHEMA-pDMAEMA synthesized via ATRP and click chemistry for gene delivery.
TL;DR: This study demonstrates that grafting a low-molecular-weight cationic polymer via a hydrolyzable linker to a neutral hydrophilic polymer is an effective approach to modulate the transfection activity and toxicity profile of gene delivery polymers.
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Synthesis and characterization of telechelic polymethacrylates via RAFT polymerization
Vgr Vincent Lima,Xulin Jiang,Jcm José Brokken-Zijp,Peter J. Schoenmakers,L Bert Klumperman,Rob van der Linde +5 more
TL;DR: The reversible addition-fragmentation chain transfer (RAFT) polymerization technique has been employed to synthesize linear α,ω -telechelic polymers with either hydroxyl or carboxyl end groups as mentioned in this paper.
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Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties.
C. Lin,Zhiyuan Zhong,Martin C. Lok,Xulin Jiang,Wim E. Hennink,Jan Feijen,Johan F.J. Engbersen +6 more
TL;DR: It is demonstrated that bioreducible poly(amido amine)s are a very promising class of polymers for safe and efficient gene delivery and variation of the disulfide content revealed that polyplexes of PAA copolymers with appropriate disulfIDE content have largely improved biophysical properties.
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Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing
TL;DR: A novel thermosensitive and pH-sensitive hydroxypropyl chitin/tannic acid/ferric ion (HPCH/TA/Fe) composite hydrogel was fabricated and showed excellent broad-spectrum antibacterial activity up to 7 days with negligible cytotoxicity.