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Xuming Jia
Researcher at University of Saskatchewan
Publications - 5
Citations - 854
Xuming Jia is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Insulin resistance & Methylglyoxal. The author has an hindex of 4, co-authored 4 publications receiving 801 citations.
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Journal ArticleDOI
Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.
TL;DR: Exogenously applied H2S significantly increased whole‐cell KATP channel currents at concentrations equal to or lower than 100 μm and markedly increased open probability by more than 2‐fold of single KATp channels (inside‐out recording) in native INS‐1E cells.
Journal ArticleDOI
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.
Lingyun Wu,Wei Yang,Xuming Jia,Guangdong Yang,Guangdong Yang,Duridanova Db,Kun Cao,Rui Wang,Rui Wang +8 more
TL;DR: New therapeutic approach for diabetes management can be devised based on the observation that insulin release is impaired in ZDF because of abnormally high pancreatic production of H2S, which was found to be generated in rat pancreas islets.
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Structural and functional changes in human insulin induced by methylglyoxal
TL;DR: MG modifies insulin by attaching to internal arginine residue in β‐chain of insulin by forming an adduct that decreases insulinmediated glucose uptake, impairs autocrine control of insulin secretion, and decreases insulin clearance.
Journal ArticleDOI
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.
TL;DR: Increased methylglyoxal, AGEs, oxidative stress and reduced eNOS along with structural remodeling of the vessel wall in the aorta and mesenteric artery likely play a role in the pathogenesis of hypertension.
Journal ArticleDOI
A low-cost and high-performance casted titanium matrix composite with Cr3C2 additions
Jiacheng Zhang,Zhong Yang,Xigang Yang,Xuming Jia,Mingnian Yang,Yongchun Guo,Jianping Li,Yang Yu +7 more
TL;DR: In this paper , a low-cost, high performance TiC reinforced titanium matrix composite was successfully fabricated using an in situ reaction casting method, and the results showed that the morphology and distribution of TiC in the microstructure were the more important factors affecting the properties of composites.