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Xunhao Xiong
Researcher at University of Oklahoma Health Sciences Center
Publications - 11
Citations - 576
Xunhao Xiong is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Cancer cell & Gene silencing. The author has an hindex of 9, co-authored 11 publications receiving 397 citations. Previous affiliations of Xunhao Xiong include University of Oklahoma.
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Journal ArticleDOI
Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth
Sounik Saha,Xunhao Xiong,Prabir K. Chakraborty,Khader Shameer,Rochelle R. Arvizo,Rachel A. Kudgus,Shailendra Kumar Dhar Dwivedi,Nazir Hossen,Elizabeth M. Gillies,J. David Robertson,Joel T. Dudley,Raul Urrutia,Russell G. Postier,Resham Bhattacharya,Priyabrata Mukherjee +14 more
TL;DR: It is demonstrated that gold nanoparticles (AuNPs) inhibit proliferation and migration of both PCCs and PSCs by disrupting the bidirectional communication via alteration of the cell secretome through the ER-stress-regulated IRE1-dependent decay pathway (RIDD).
Journal ArticleDOI
MICU1 drives glycolysis and chemoresistance in ovarian cancer
Prabir K. Chakraborty,Soumyajit Banerjee Mustafi,Xunhao Xiong,Shailendra Kumar Dhar Dwivedi,Vasyl Nesin,Sounik Saha,Min Zhang,Danny N. Dhanasekaran,Muralidharan Jayaraman,Robert S. Mannel,Kathleen N. Moore,Scott McMeekin,Da Yang,Rosemary E. Zuna,Kai Ding,Leonidas Tsiokas,Resham Bhattacharya,Priyabrata Mukherjee +17 more
TL;DR: It is demonstrated that the gatekeeper of mitochondrial Ca2+ uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer, and a significant correlation between pPDH (inactive form of PDH) expression with poor prognosis is observed.
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Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration
Sounik Saha,Prabir K. Chakraborty,Xunhao Xiong,Shailendra Kumar Dhar Dwivedi,Soumyajit Banerjee Mustafi,Noah R. Leigh,Ramani Ramchandran,Priyabrata Mukherjee,Resham Bhattacharya +8 more
TL;DR: It is shown that the loss of CBS function in endothelial cells (ECs) leads to a significant down‐regulation of cellular hydrogen sulfide (H2S) by 50% and of glutathione (GSH) by 40%, highlighting the importance of CBS‐mediated protein S‐sulfhydration in maintaining vascular health and function.
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Sensitization of ovarian cancer cells to cisplatin by gold nanoparticles.
Xunhao Xiong,Rochelle R. Arvizo,Sounik Saha,J. David Robertson,Scott McMeekin,Resham Bhattacharya,Priyabrata Mukherjee +6 more
TL;DR: By depleting stem cell pools and inhibiting key molecular pathways gold nanoparticles sensitize ovarian cancer cells to cisplatin and may be used in combination to inhibit tumor growth and metastasis in ovarian cancer.
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Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer
Anindya Dey,Xunhao Xiong,A.K. Crim,Shailendra Kumar Dhar Dwivedi,Soumyajit Banerjee Mustafi,Priyabrata Mukherjee,Liangxian Cao,Nadiya Sydorenko,Ramil Baiazitov,Young Choon Moon,Melissa Dumble,Thomas W. Davis,Resham Bhattacharya,Resham Bhattacharya +13 more
TL;DR: In vivo, orally administered PTC-028, as a single agent, exhibits significant antitumor activity comparable with the standard cisplatin/paclitaxel therapy in an orthotopic mouse model of ovarian cancer, demonstrating the potential to be used as an effective therapeutic agent in patients with epithelial ovarian cancer where treatment options are limited.