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Xupeng Yang
Researcher at Shanghai Jiao Tong University
Publications - 8
Citations - 109
Xupeng Yang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Chemistry & Cancer research. The author has an hindex of 3, co-authored 5 publications receiving 16 citations.
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Journal ArticleDOI
Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance.
Yanhua Zhang,Yang Dong,Hao Fu,Hui Huang,Zhihua Wu,Meng Zhao,Xupeng Yang,Qianqian Guo,Yourong Duan,Ying Sun +9 more
TL;DR: NPs-cRGD with ultrasound promoted the apoptosis of resistant ovarian cancer cells by multiple mechanisms, including increased cellular drug accumulation, reversed antiapoptotic effects by siBIRC5, and enhanced ROS levels.
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Nano-ultrasonic Contrast Agent for Chemoimmunotherapy of Breast Cancer by Immune Metabolism Reprogramming and Tumor Autophagy.
Xupeng Yang,Meng Zhao,Zhihua Wu,Chuanrong Chen,Yanhua Zhang,Liting Wang,Qianqian Guo,Quan Wang,Shunshun Liang,Suxian Hu,Yourong Duan,Ying Sun +11 more
TL;DR: The tumor microenvironment-responsive nano-ultrasonic contrast agent Pt(IV)/CQ/PFH NPs-DPPA-1 boosts the ratio of mature dendritic cells (mDCs) and proinflammatory macrophages by reprogramming the metabolism of immature DCs and tumor-associated macrophage (TAMs) by reducing platinum(IV) in cancer cells or iDCs to cisplatin.
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Immune/Hypoxic Tumor Microenvironment Regulation-Enhanced Photodynamic Treatment Realized by pH-Responsive Phase Transition-Targeting Nanobubbles.
TL;DR: In this paper, a novel tumor-targeted nanosized ultrasound contrast nanobble loaded with chlorin e6 (Ce6), metformin (MET), and perfluorohexane (PFH) was fabricated.
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Sequential Release of Pooled siRNAs and Paclitaxel by Aptamer-Functionalized Shell-Core Nanoparticles to Overcome Paclitaxel Resistance of Prostate Cancer
Qianqian Guo,Yang Dong,Yanhua Zhang,Hao Fu,Chuanrong Chen,Liting Wang,Xupeng Yang,Ming Shen,Jian Yu,Meiwan Chen,Jiali Zhang,Yourong Duan +11 more
TL;DR: In this paper, the authors developed prostatespecific membrane antigen aptamer (Apt)-functionalized shell-core nanoparticles (PTX/siRNAs NPs-Apt) to overcome PTX-resistant LNCaP/PTX cells.
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Multi-Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation
Liting Wang,Qing Shen,Hongze Liao,Hao Fu,Qi Wang,Jian Yu,Wei Zhang,Chuanrong Chen,Yang Dong,Xupeng Yang,Qianqian Guo,Jiali Zhang,Jian Zhang,Hou-Wen Lin,Yourong Duan +14 more
TL;DR: In this article, the authors reported the first inhibitor of DR6/APP interaction as a novel class of anti-hematogenous metastatic agent, which is obtained by rationally utilizing three combined strategies including selection based on phage display library, d-retro-inverso modification, and multiple conjugation of screened peptidomimetic with 4-arm PEG.