Showing papers in "Biomaterials in 2021"

TL;DR: In this article, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed, and functional materials with GSH consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials.

TL;DR: An exosome-based dual delivery biosystem for enhancing PDAC immunotherapy as well as reversing tumor immunosuppression of M2-like tumor associated macrophages (M2-TAMs) upon disruption of galectin-9/dectin 1 axis is demonstrated.

TL;DR: This work declares the first example of using bio-active nanoparticles for RA treatment without loading any drugs, and highlights the potential of FA-AgNPs for targeted RA therapy via simultaneous M1 macrophage apoptosis and M1-to-M2 macrophages re-polarization.

TL;DR: The superior biological functions and powerful therapeutic potential of EVs are clarified, particularly with regard to new designs based on EVs and their utilization in a new generation of nanomedicine diagnosis and treatment platforms.

TL;DR: A novel double cross-linked multifunctional hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond is a promising candidate as a dynamic burn wound dressing and shortened the healing time of burn wounds to 13 days, and accelerated the reconstruction of skin structure and function.

TL;DR: The study suggests that the hot spring-mimetic approach may be an effective strategy to design bioactive materials for promoting angiogenesis and tissue regeneration.

TL;DR: The alleviated hypoxia is found to be critical to the enhancement of PDT efficacy, reversal of cisplatin resistance in tumors, and polarization of tumor-associated macrophages to the immunocompetent M1-phynotype.

TL;DR: An ultrasound (US)-activatable nanomedicine was developed for overcoming hypoxia-induced resistance to chemotherapy and efficiently inhibiting tumor growth by inducing sensitized apoptosis and collaborative ferroptosis of tumor cells, showing great potential as theranostic agents for hypoxic solid tumors treatment.

TL;DR: Targeted delivery of Kartogenin to SF-MSCs by engineered exosomes leads to even dispersion of KGN in the cytosol, increases its effective concentration in the cell, and strongly promotes the chondrogenesis of SF- MSCs in vitro and in vivo.

TL;DR: Different common strategies for carrier-free nanodrugs preparation are summarized, mainly including nanoprecipitation, template-assisted nanoprecIPitation, thin-film hydration, spray-drying technique, supercritical fluid (SCF) technique, and wet media milling.

TL;DR: The findings indicate that C16-R848 adjuvant pulsation to mRNA vaccine NP is a rational design strategy to increase the effectiveness of synthetic mRNA vaccines for cancer immunotherapy.

TL;DR: In this article, a bioinspired neutrophil-exosomes (NEs-Exos) system for delivering loaded doxorubicin (DOX) drug for glioma treatment is proposed and systematically investigated.

TL;DR: The role of abnormal ECM homeostasis in the joint cartilage during OA is summarized and an update is provided on the cartilage ECM derived biomarkers and regenerative medicine therapies targeting cartilageECM which includes preclinical animal models study and clinical trials.

TL;DR: In vitro biological experiments indicated that the stratified fiber-reinforced and growth factor-loaded hydrogel construct induced the MSCs to differentiate down both the chondrogenic and osteogenic lineages and that the engineered complex exhibited cellular phenotype and matrix accumulation profiles resembling those of the native tissue.

TL;DR: In the NIR-II region, small organic molecule fluorophore has attracted much attention because of its good biocompatibility and good pharmacokinetic properties, and a reasonable prospect is made for the development of small organic molecules as mentioned in this paper.

TL;DR: A review of microfluidic technologies for the formulation of nanoparticles can be found in this article, with an emphasis on lipid-based nanoparticles, polymeric NPs, and inorganic NPs.

TL;DR: The obtained MoS2-CuO@BSA/R837 (MCBR) nanoplatforms realize the excellent computed tomography/infrared thermal/magnetic resonance multi-mode bioimaging as well as significantly enhanced antitumor efficacy of synergetic photothermal therapy (PTT)/chemodynamic therapy (CDT)/immunotherapy.

TL;DR: This critical review will focus on principles and methods in the design of bone-targeted nanoparticles for the early detection of bone metastatic tumors and the ablation of cancer via chemotherapy, photothermal therapy, gene therapy and combination therapy.

TL;DR: Wang et al. as discussed by the authors fabricated NSC-laden scaffolds by 3D bioprinting and explore for the first time their application for in vivo SCI repair.

TL;DR: 3D surface topography, whether intended or unintended, is an important consideration in the rational design of safe medical devices and future research on next-generation smart antifouling materials could benefit from a greater focus on translation to real-world applications.

TL;DR: In this article, a simple multifunctional nanocomposite was fabricated by coating red light-excited photosensitizer chlorin e6 (Ce6) onto nanoceria, achieving simultaneous sterilization and inflammation elimination via a dual directional regulation effect.

TL;DR: The authors harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhibition of tumor growth by reprogramming TAMs into M1-like macrophages.

TL;DR: This review will summarize recently developed advanced Nir-II inorganic PTAs based on the dominant inorganic elements and provide a comparison of their NIR-II photothermal performances.

TL;DR: The strategy using the combined treatment of biomaterials, stem cells, and acupuncture reveals a perspective new approach to accelerate the tissue regeneration.

TL;DR: In this article, a lipid-based micellar nanocarrier encapsulating sonosensitizer chlorin e6 (Ce6) in the core, conjugating anti-PD-L1 antibody (aPD)-L1 to the interlayer through MMP-2-cleavable peptide, and bearing a PEG coating sheddable at low pH value (≈6.5) of tumor microenvironment.

TL;DR: In this paper, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration in the early stage of osteoarthritis.

TL;DR: It is suggested that exogenously administered long-acting nanoparticulate DNase-1 can effectively reduce cfDNA levels and neutrophil activities and may be used as a potential therapeutic intervention for life-threatening SARS-CoV-2-mediated illnesses.

TL;DR: In this paper, the role of macrophages in ECM assembly and the progression of the foreign body response is investigated using in vitro models with physiologically relevant macrophage phenotypes, as well as controlled release of macophage-modulating cytokines from gelatin hydrogels implanted subcutaneously in vivo.

TL;DR: This review highlighted the latest advancements of AIEgen-based biofunctional materials and systems in this research field and found that the AIEgens-based photosensitizers with strong photosensitization show good performance on the efficient elimination of multidrug-resistant bacteria and intracellular bacteria.

TL;DR: In this review, recent progress on free radicals and their applications in cancer theranostics are presented and typical materials that exhibit controlled generation of free radicals are summarized and discussed.