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Y.S. Babu
Researcher at Durham University
Publications - 25
Citations - 1489
Y.S. Babu is an academic researcher from Durham University. The author has contributed to research in topics: Virus & BCX4430. The author has an hindex of 13, co-authored 25 publications receiving 1282 citations.
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Journal ArticleDOI
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
Travis K. Warren,Jay Wells,Rekha G. Panchal,Kelly S. Stuthman,Nicole L. Garza,Sean A. Van Tongeren,Lian Dong,Cary Retterer,Brett P. Eaton,Gianluca Pegoraro,Shelley P. Honnold,Shanta Bantia,Pravin L. Kotian,Xilin Chen,Brian R. Taubenheim,Lisa S. Welch,Dena M. Minning,Y.S. Babu,William P. Sheridan,Sina Bavari +19 more
TL;DR: It is shown that BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells, and exhibits broad-spectrum antiviral activity against numerous viruses.
Journal ArticleDOI
BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Raymond Taylor,Pravin L. Kotian,Travis K. Warren,Rekha G. Panchal,Sina Bavari,Justin G. Julander,Sylvia Dobo,Angela Rose,Yahya El-Kattan,Brian R. Taubenheim,Y.S. Babu,William P. Sheridan +11 more
TL;DR: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Journal ArticleDOI
Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir
Shanta Bantia,C. D. Parker,Sandya L Ananth,L. L. Horn,Koenraad Jozef Lodewijk Marcel Andries,Pooran Chand,Pravin L. Kotian,A. Dehghani,Y. El-Kattan,Tsu-Hsing Lin,T. L. Hutchison,John A. Montgomery,D. L. Kellog,Y.S. Babu +13 more
TL;DR: The potency of three compounds, RWJ-270201, oseltamivir, and zanamvir, against neuraminidase enzymes from various subtypes of influenza are compared to show excellent selectivity for influenza virus neuraminidsase over mammalian, bacterial, or other viral neuramineidases.
Journal ArticleDOI
Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model.
Justin G. Julander,Venkatraman Siddharthan,Joe Evans,Ray Taylor,Kelsey Tolbert,Chad Apuli,Jason Stewart,Preston A. Collins,Makda S. Gebre,Skot Neilson,Arnaud J. Van Wettere,Young-Min Lee,William P. Sheridan,John D. Morrey,Y.S. Babu +14 more
TL;DR: The demonstration of potent activity of BCX4430 against ZIKV in a lethal mouse model warrant its continued clinical development.
Journal ArticleDOI
In Vivo Influenza Virus-Inhibitory Effects of the Cyclopentane Neuraminidase Inhibitor RWJ-270201
Robert W. Sidwell,Donald F. Smee,John H. Huffman,Dale L. Barnard,Kevin W. Bailey,John D. Morrey,Y.S. Babu +6 more
TL;DR: There is potential for the oral use of RWJ-270201 in the treatment of influenza virus infections in humans, based on evaluated against influenza A/NWS/33, A/Shangdong/09/93, and B/Hong Kong/05/72 viruses infections in mice.