R
Rekha G. Panchal
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 42
Citations - 1915
Rekha G. Panchal is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Burkholderia mallei. The author has an hindex of 19, co-authored 42 publications receiving 1673 citations. Previous affiliations of Rekha G. Panchal include National Institutes of Health & United States Department of the Army.
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Journal ArticleDOI
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
Travis K. Warren,Jay Wells,Rekha G. Panchal,Kelly S. Stuthman,Nicole L. Garza,Sean A. Van Tongeren,Lian Dong,Cary Retterer,Brett P. Eaton,Gianluca Pegoraro,Shelley P. Honnold,Shanta Bantia,Pravin L. Kotian,Xilin Chen,Brian R. Taubenheim,Lisa S. Welch,Dena M. Minning,Y.S. Babu,William P. Sheridan,Sina Bavari +19 more
TL;DR: It is shown that BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells, and exhibits broad-spectrum antiviral activity against numerous viruses.
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A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
Peter B. Madrid,Sidharth Chopra,Ian D. Manger,Lynne Gilfillan,Tiffany R. Keepers,Amy C. Shurtleff,Carol E. Green,Lalitha V. Iyer,Holli Hutcheson Dilks,Robert A. Davey,Andrey A. Kolokoltsov,Ricardo Carrion,Jean L. Patterson,Sina Bavari,Rekha G. Panchal,Travis K. Warren,Jay Wells,Walter H. Moos,RaeLyn L. Burke,Mary J. Tanga +19 more
TL;DR: The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.
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BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Raymond Taylor,Pravin L. Kotian,Travis K. Warren,Rekha G. Panchal,Sina Bavari,Justin G. Julander,Sylvia Dobo,Angela Rose,Yahya El-Kattan,Brian R. Taubenheim,Y.S. Babu,William P. Sheridan +11 more
TL;DR: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Journal ArticleDOI
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James C. Burnett,Gordon Ruthel,Christian Stegmann,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Robert G. Stafford,Douglas Lane,Tara Kenny,Connor F. McGrath,Peter Wipf,Andrea M. Stahl,James J. Schmidt,Rick Gussio,Axel T. Brunger,Sina Bavari +15 more
TL;DR: Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein in a primary culture of embryonic chicken neurons.
Journal ArticleDOI
Identification of an antioxidant small-molecule with broad-spectrum antiviral activity
Rekha G. Panchal,St. Patrick Reid,Julie P. Tran,Alison A. Bergeron,Jay Wells,Krishna P. Kota,Javad Aman,Sina Bavari +7 more
TL;DR: Small molecule chemical screening for Ebola virus inhibitors resulted in identification of a compound NSC 62914, which was found to exhibit anti-filovirus activity in cell-based assays and in vivo protected mice following challenge with Ebola or Marburg viruses.