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Y. T. Hu
Researcher at Huazhong University of Science and Technology
Publications - 15
Citations - 210
Y. T. Hu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Nav1.5 & Piezoelectricity. The author has an hindex of 8, co-authored 15 publications receiving 136 citations. Previous affiliations of Y. T. Hu include Central South University.
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Journal ArticleDOI
De novo loss-of-function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes
Lina Liang,Xia Li,Sebastien Moutton,Samantha A. Schrier Vergano,Benjamin Cogné,Anne de Saint-Martin,Anna C.E. Hurst,Y. T. Hu,Olaf Bodamer,Olaf Bodamer,Julien Thevenon,Christina Hung,Bertrand Isidor,Bénédicte Gérard,Adelaide Rega,Sophie Nambot,Daphné Lehalle,Yannis Duffourd,Christel Thauvin-Robinet,Laurence Faivre,Stéphane Bézieau,Leon S. Dure,Daniel Helbling,David P. Bick,Chengqi Xu,Qiuyun Chen,Grazia M.S. Mancini,Antonio Vitobello,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang +30 more
TL;DR: Phenotypic analysis of the patients carrying the recurrent p.(Gly375Arg) de novo missense LoF variant revealed a novel syndromic neurodevelopmental disorder associated with severe developmental delay, visceral and cardiac malformations, connective tissue presentations with arterial involvement, bone dysplasia and characteristic dysmorphic features.
Journal ArticleDOI
Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5.
Zhijie Wang,Gang Yu,Yinan Liu,Shiyong Liu,Meir Aridor,Yuan Huang,Y. T. Hu,Longfei Wang,Sisi Li,Hongbo Xiong,Bo Tang,Xia Li,Chen Cheng,Susmita Chakrabarti,Fan Wang,Qingyu Wu,Sadashiva S. Karnik,Chengqi Xu,Qiuyun Chen,Qiuyun Chen,Qing Kenneth Wang +20 more
TL;DR: These data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5, and interactions with MOG1, a small protein involved in regulation of the endoplasmic reticulum exit of Nav2, are reported to interact with RAN.
Journal ArticleDOI
Surface waves in electrostrictive materials under biasing fields
Y. T. Hu,Jie Yang,Qing Jiang +2 more
TL;DR: In this paper, the theory of small incremental fields superposed on finite biasing fields in an electroelastic body is summarized and applied to two-dimensional anisotropic elasticity and piezoelectricity.
Journal ArticleDOI
UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density.
Bo Tang,Y. T. Hu,Zhijie Wang,Chen Cheng,Pengyun Wang,Lina Liang,Hongbo Xiong,Chunyan Luo,Chengqi Xu,Qiuyun Chen,Qiuyun Chen,Qing Kenneth Wang +11 more
TL;DR: It is shown that UBC9, a SUMO-conjugating enzyme, regulates ubiquitination and degradation of Nav1.5, and co-immunoprecipitation showed that U BC9 interacts with Nedd4-2, which acts as an E3 ubiquitin-protein ligase involved in ubiquitine-protein degradation and regulates Nav 1.5 expression levels in asumOylation-independent manner.
Journal ArticleDOI
Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Nav1.5 clarify the molecular basis of Brugada syndrome.
Gang Yu,Yinan Liu,Jun Qin,Zhijie Wang,Zhijie Wang,Y. T. Hu,Fan Wang,Yabo Li,Susmita Chakrabarti,Qiuyun Chen,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang +12 more
TL;DR: The effects of defined MOG1 deletions and alanine-scanning substitutions are assessed to improve the understanding of how the E83D substitution causes BrS and identify the structural elements in Mog1 that are crucial for its interaction with Nav1.5.