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Qiuyun Chen
Researcher at Cleveland Clinic Lerner College of Medicine
Publications - 49
Citations - 1447
Qiuyun Chen is an academic researcher from Cleveland Clinic Lerner College of Medicine. The author has contributed to research in topics: Genome-wide association study & Gene knockdown. The author has an hindex of 18, co-authored 49 publications receiving 1083 citations. Previous affiliations of Qiuyun Chen include Cleveland Clinic Lerner Research Institute & Case Western Reserve University.
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Journal ArticleDOI
Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death
Xianqin Zhang,Xianqin Zhang,Shenghan Chen,Shin Yoo,Susmita Chakrabarti,Teng Zhang,Tie Ke,Tie Ke,Carlos Oberti,Sandro L. Yong,Fang Fang,Fang Fang,Lin Li,Roberto de la Fuente,Lejin Wang,Lejin Wang,Qiuyun Chen,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang +19 more
TL;DR: Human and mouse studies indicate that loss of NUP155 function causes AF by altering mRNA and protein transport and link the NPC to cardiovascular disease.
Journal ArticleDOI
Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5
Ling Wu,Ling Wu,Sandro L. Yong,Chun Fan,Ying Ni,Shin Yoo,Teng Zhang,Xianqin Zhang,Carlos A. Obejero-Paz,Hyun Jin Rho,Tie Ke,Przemyslaw Szafranski,Stephen W. Jones,Qiuyun Chen,Qing Kenneth Wang +14 more
TL;DR: It is reported that MOG1, a small protein that is highly conserved from yeast to humans, is a central component of the channel complex and modulates the physiological function of Nav1.5.
Journal ArticleDOI
Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population
Pengyun Wang,Qinbo Yang,Qinbo Yang,Xiaofen Wu,Xiaofen Wu,Yanzong Yang,Lisong Shi,Chuchu Wang,Gang Wu,Yunlong Xia,Bo Yang,Rongfeng Zhang,Chengqi Xu,Xiang Cheng,Sisi Li,Yuanyuan Zhao,Fenfen Fu,Yuhua Liao,Fang Fang,Fang Fang,Qiuyun Chen,Xin Tu,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang +24 more
TL;DR: A novel A130V mutation was identified in a 46-year-old patient with lone AF, and the mutation was absent in 500 controls, suggesting that mutations in SCN3B may be a new pathogenic cause of AF.
Journal ArticleDOI
Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population
Qinbo Yang,Lin Li,Lin Li,Qiuyun Chen,Qiuyun Chen,Nancy Foldvary-Schaefer,Nancy Foldvary-Schaefer,William G. Ondo,Qing Kenneth Wang +8 more
TL;DR: Variants in MEIS1, BTBD9, and MAP2K5/SKOR1 confer a significant risk of RLS in a US population and are investigated to validate the GWAS findings.
Journal ArticleDOI
De novo loss-of-function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes
Lina Liang,Xia Li,Sebastien Moutton,Samantha A. Schrier Vergano,Benjamin Cogné,Anne de Saint-Martin,Anna C.E. Hurst,Y. T. Hu,Olaf Bodamer,Olaf Bodamer,Julien Thevenon,Christina Hung,Bertrand Isidor,Bénédicte Gérard,Adelaide Rega,Sophie Nambot,Daphné Lehalle,Yannis Duffourd,Christel Thauvin-Robinet,Laurence Faivre,Stéphane Bézieau,Leon S. Dure,Daniel Helbling,David P. Bick,Chengqi Xu,Qiuyun Chen,Grazia M.S. Mancini,Antonio Vitobello,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang +30 more
TL;DR: Phenotypic analysis of the patients carrying the recurrent p.(Gly375Arg) de novo missense LoF variant revealed a novel syndromic neurodevelopmental disorder associated with severe developmental delay, visceral and cardiac malformations, connective tissue presentations with arterial involvement, bone dysplasia and characteristic dysmorphic features.