Z
Zhijie Wang
Researcher at Huazhong University of Science and Technology
Publications - 12
Citations - 185
Zhijie Wang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Nav1.5 & Sudden death. The author has an hindex of 5, co-authored 9 publications receiving 106 citations. Previous affiliations of Zhijie Wang include Cleveland Clinic Lerner College of Medicine.
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Journal ArticleDOI
Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p
Yuanyuan Zhao,Yuan Huang,Weihua Li,Zhijie Wang,Shaopeng Zhan,Mengchen Zhou,Yufeng Yao,Zhipeng Zeng,Yuxi Hou,Qiuyun Chen,Xin Tu,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang,Zhengrong Huang +14 more
TL;DR: A novel post-transcriptional regulatory mechanism for expression and function of SCN5A/Nav1.5 via miR-192-5p is revealed and a new target for novel miRNA-based antiarrhythmic therapy for diseases with reduced INa is provided.
Journal ArticleDOI
αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5
Yuan Huang,Zhijie Wang,Yinan Liu,Hongbo Xiong,Yuanyuan Zhao,Ling Wu,Chao Yuan,Longfei Wang,Yuxi Hou,Gang Yu,Zhengrong Huang,Chengqi Xu,Qiuyun Chen,Qing Kenneth Wang,Qing Kenneth Wang +14 more
TL;DR: αB-Crystallin is identified as a new binding partner for Nav1.5, which requires the protein-protein interactions between αB-crystallin and Nav1 the pore-forming α subunit of the cardiac voltage-gated Na+ channel complex.
Journal ArticleDOI
Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5.
Zhijie Wang,Gang Yu,Yinan Liu,Shiyong Liu,Meir Aridor,Yuan Huang,Y. T. Hu,Longfei Wang,Sisi Li,Hongbo Xiong,Bo Tang,Xia Li,Chen Cheng,Susmita Chakrabarti,Fan Wang,Qingyu Wu,Sadashiva S. Karnik,Chengqi Xu,Qiuyun Chen,Qiuyun Chen,Qing Kenneth Wang +20 more
TL;DR: These data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5, and interactions with MOG1, a small protein involved in regulation of the endoplasmic reticulum exit of Nav2, are reported to interact with RAN.
Journal ArticleDOI
UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density.
Bo Tang,Y. T. Hu,Zhijie Wang,Chen Cheng,Pengyun Wang,Lina Liang,Hongbo Xiong,Chunyan Luo,Chengqi Xu,Qiuyun Chen,Qiuyun Chen,Qing Kenneth Wang +11 more
TL;DR: It is shown that UBC9, a SUMO-conjugating enzyme, regulates ubiquitination and degradation of Nav1.5, and co-immunoprecipitation showed that U BC9 interacts with Nedd4-2, which acts as an E3 ubiquitin-protein ligase involved in ubiquitine-protein degradation and regulates Nav 1.5 expression levels in asumOylation-independent manner.
Journal ArticleDOI
Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Nav1.5 clarify the molecular basis of Brugada syndrome.
Gang Yu,Yinan Liu,Jun Qin,Zhijie Wang,Zhijie Wang,Y. T. Hu,Fan Wang,Yabo Li,Susmita Chakrabarti,Qiuyun Chen,Qing Kenneth Wang,Qing Kenneth Wang,Qing Kenneth Wang +12 more
TL;DR: The effects of defined MOG1 deletions and alanine-scanning substitutions are assessed to improve the understanding of how the E83D substitution causes BrS and identify the structural elements in Mog1 that are crucial for its interaction with Nav1.5.