Y
Ya Zhang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 10
Citations - 1274
Ya Zhang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 8, co-authored 10 publications receiving 984 citations.
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Journal ArticleDOI
Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes
Hiroko Masuda,Keith A. Baggerly,Ying Wang,Ya Zhang,Ana M. Gonzalez-Angulo,Funda Meric-Bernstam,Vicente Valero,Brian D. Lehmann,Jennifer A. Pietenpol,Gabriel N. Hortobagyi,W. Fraser Symmans,Naoto T. Ueno +11 more
TL;DR: The clinical relevancy of the 7-subtype classification of triple-negative breast cancer reported by Lehmann and colleagues is confirmed, and may spur innovative personalized medicine strategies for patients with TNBC.
Journal ArticleDOI
Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype.
W. Fraser Symmans,Caimiao Wei,Rebekah Gould,Xian Yu,Ya Zhang,Mei Liu,Andrew Walls,Alex Bousamra,Maheshwari Ramineni,Bruno Valentin Sinn,Kelly K. Hunt,Thomas A. Buchholz,Vicente Valero,Aman U. Buzdar,Wei Yang,Abenaa M. Brewster,Stacy L. Moulder,Lajos Pusztai,Christos Hatzis,Gabriel N. Hortobagyi +19 more
TL;DR: Continuous RCB index was prognostic for long-term survival after neoadjuvant chemotherapy in all three phenotypic subsets of breast cancer and stratified prognostic risk overall, within each phenotypesic subset, and within yp-stage categories.
Journal ArticleDOI
Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor–Positive Breast Cancer
Enrique Fuentes-Mattei,Guermarie Velazquez-Torres,Liem Phan,Fanmao Zhang,Ping Chieh Chou,Ji Hyun Shin,Hyun Ho Choi,Jiun Sheng Chen,Ruiying Zhao,Jian Chen,Christopher Gully,Colin Carlock,Yuan Qi,Ya Zhang,Yun Wu,Francisco J. Esteva,Yongde Luo,Wallace L. McKeehan,Joe Ensor,Gabriel N. Hortobagyi,Lajos Pusztai,W. Fraser Symmans,Mong Hong Lee,Sai Ching J. Yeung +23 more
TL;DR: Adipokine secretion and AKT/mTOR activation play important roles in obesity-accelerated breast cancer aggressiveness in addition to hyperinsulinemia, estrogen signaling, and inflammation.
Journal ArticleDOI
Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer.
Christos Hatzis,W. Fraser Symmans,Ya Zhang,Rebekah Gould,Stacy L. Moulder,Kelly K. Hunt,Maysa M. Abu-Khalaf,Erin Hofstatter,Donald R. Lannin,Anees B. Chagpar,Lajos Pusztai +10 more
TL;DR: A framework for understanding the relationship between pCR and overall survival benefit that can help inform the design of neoadjuvant trials aiming to demonstrate improved survival from a regimen that results in higher pCR rate is provided.
Journal ArticleDOI
SETER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer.
Bruno Valentin Sinn,Bruno Valentin Sinn,Chunxiao Fu,Rosanna Lau,Jennifer K. Litton,Tsung-Heng Tsai,Rashmi Krishna Murthy,Alda L. Tam,Eleni Andreopoulou,Eleni Andreopoulou,Yun Gong,Ravi Murthy,Rebekah Gould,Ya Zhang,Tari A. King,Agnes Viale,Victor P. Andrade,Dilip Giri,Roberto Salgado,Ioanna Laïos,Christos Sotiriou,Esmeralda Celia Marginean,Danielle N. Kwiatkowski,Rachel M. Layman,Daniel J. Booser,Christos Hatzis,Vicente Valero,W. Fraser Symmans +27 more
TL;DR: Elevated SETER/PR was associated with prolonged sensitivity to endocrine therapy in patients with metastatic HR+/HER2− breast cancer, especially in the absence of mutated ESR1 transcript.