L
Liem Phan
Researcher at University of Texas MD Anderson Cancer Center
Publications - 34
Citations - 1826
Liem Phan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Ubiquitin ligase. The author has an hindex of 20, co-authored 32 publications receiving 1455 citations. Previous affiliations of Liem Phan include University of Texas at Austin & University of Texas Health Science Center at Houston.
Papers
More filters
Journal ArticleDOI
Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies.
TL;DR: This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
Journal ArticleDOI
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression.
Ryan Kolb,Liem Phan,Liem Phan,Nicholas Borcherding,Yinghong Liu,Fang Yuan,Ann M. Janowski,Qing Xie,Kathleen R. Markan,Wei Li,Matthew J. Potthoff,Enrique Fuentes-Mattei,Lesley G. Ellies,C. Michael Knudson,Mong Hong Lee,Sai Ching J. Yeung,Sai Ching J. Yeung,Suzanne L. Cassel,Suzanne L. Cassel,Fayyaz S. Sutterwala,Fayyaz S. Sutterwala,Weizhou Zhang +21 more
TL;DR: A causal mechanism by which obesity promotes breast cancer progression is provided and a foundation to block NLRC4 inflammasome activation or IL-1β signalling transduction is laid out that may be useful for the treatment of obese cancer patients.
Journal ArticleDOI
Aurora B kinase phosphorylates and instigates degradation of p53
Christopher Gully,Guermarie Velazquez-Torres,Ji Hyun Shin,Enrique Fuentes-Mattei,Edward Wang,Edward Wang,Colin Carlock,Colin Carlock,Jian Chen,Daniel A. Rothenberg,Henry P. Adams,Hyun Ho Choi,Sergei Guma,Sergei Guma,Liem Phan,Ping Chieh Chou,Ping Chieh Chou,Chun Hui Su,Chun Hui Su,Fanmao Zhang,Fanmao Zhang,Jiun Sheng Chen,Tsung Ying Yang,Sai Ching J. Yeung,Mong Hong Lee +24 more
TL;DR: It is implied that oncogenic hyperactivation or overexpression of Aurora B may compromise the tumor suppressor function of p53, and the antineoplastic mechanism for Aurora B kinase inhibitors in cancer cells with WT p53 is clarified.
Journal ArticleDOI
Roles of COP9 signalosome in cancer.
TL;DR: The mechanisms by which some CSN subunits are involved in cancer are discussed to provide a much needed perspective regarding COP9 in cancer research, hoping that these insights will lay the groundwork for cancer intervention.
Journal ArticleDOI
Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway
Jian Chen,Sobia Zaidi,Shuyun Rao,Jiun Sheng Chen,Liem Phan,Patrizia Farci,Xiaoping Su,Kirti Shetty,Jon White,Fausto Zamboni,Xifeng Wu,Asif Rashid,Nagarajan Pattabiraman,Raja Mazumder,Anelia Horvath,Ray-Chang Wu,Shulin Li,Cuiying Xiao,Chu-Xia Deng,Chu-Xia Deng,David A. Wheeler,Bibhuti Mishra,Bibhuti Mishra,Rehan Akbani,Lopa Mishra,Lopa Mishra +25 more
TL;DR: The findings indicate that therapeutic agents for HCCs can be effective, based on genetic features of the TGF-β pathway; agents that block TGF -β should be used only in patients with specific types of H CCs.