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Yafei Huang
Researcher at Huazhong University of Science and Technology
Publications - 25
Citations - 436
Yafei Huang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: T cell & Interleukin 21. The author has an hindex of 12, co-authored 19 publications receiving 389 citations. Previous affiliations of Yafei Huang include National Jewish Health & University of Colorado Denver.
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Journal ArticleDOI
Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells
Lan Cheng,Yan Cui,Yan Cui,Hui Shao,Gencheng Han,Ling Zhu,Yafei Huang,Rebecca L. O'Brien,Willi K. Born,Henry J. Kaplan,Deming Sun,Deming Sun +11 more
TL;DR: It is shown that gammadelta T cells derived from immunized mice also can be induced to express MHC class II and co-stimulatory molecules after activation in vitro, and are capable of antigen presentation.
Journal ArticleDOI
The Influence of IgE-Enhancing and IgE-Suppressive γδ T Cells Changes with Exposure to Inhaled Ovalbumin
Yafei Huang,Niyun Jin,Christina L. Roark,M. Kemal Aydintug,J. M. Wands,Hua Huang,Rebecca L. O'Brien,Willi K. Born +7 more
TL;DR: Airway allergen challenge differentially affects two distinct subsets of γδ T cells with nonoverlapping functional potentials, and the outcome is IgE suppression.
Journal ArticleDOI
γδ T cells affect IL-4 production and B-cell tolerance
Yafei Huang,Ryan A. Heiser,Thiago Detanico,Andrew Getahun,Greg A. Kirchenbaum,Tamara L. Casper,M. Kemal Aydintug,Simon R. Carding,Koichi Ikuta,Hua Huang,John C. Cambier,Lawrence J. Wysocki,Rebecca L. O'Brien,Willi K. Born +13 more
TL;DR: It is shown that γδ T cells modulate systemic antibody levels in nonimmunized mice, including all major subclasses and especially IgE antibodies, and recommended that removing IL-4 abrogated the increases in IgE, antichromatin antibody, and autoantibodies in the partiallyδ-deficient mice.
Journal ArticleDOI
γδ T Cells Shape Preimmune Peripheral B Cell Populations.
Yafei Huang,Andrew Getahun,Ryan A. Heiser,Thiago Detanico,Katja Aviszus,Greg A. Kirchenbaum,Tamara L. Casper,Chunjian Huang,M. Kemal Aydintug,Simon R. Carding,Koichi Ikuta,Hua Huang,Lawrence J. Wysocki,John C. Cambier,Rebecca L. O'Brien,Willi K. Born +15 more
TL;DR: The capability of γδ T cells of modulating size and productivity of preimmune peripheral B cell populations is demonstrated, and evidence suggests the possibility of direct interactions between γ Δ T cells and B cells in the splenic MZ.
Journal ArticleDOI
A canonical Vγ4Vδ4+ γδ T cell population with distinct stimulation requirements which promotes the Th17 response
Christina L. Roark,Yafei Huang,Yafei Huang,Niyun Jin,Niyun Jin,M. Kemal Aydintug,M. Kemal Aydintug,Tamara L. Casper,Tamara L. Casper,Deming Sun,Willi K. Born,Willi K. Born,Rebecca L. O'Brien,Rebecca L. O'Brien +13 more
TL;DR: It is reported that CFA emulsified with PBS alone (without collagen) is sufficient to induce a strong response of Vγ4Vδ4+ cells in the draining lymph nodes of DBA/1 and C57BL/6 mice and that the TCRs of the elicited Vγ 4V γδ T cells in both strains heavily favor the canonical sequence.