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Yamila Verdecia-Reyes
Researcher at University of Havana
Publications - 13
Citations - 210
Yamila Verdecia-Reyes is an academic researcher from University of Havana. The author has contributed to research in topics: Neuroprotection & Oxidative stress. The author has an hindex of 7, co-authored 13 publications receiving 166 citations.
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A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo
Yanier Nuñez-Figueredo,Jeney Ramírez-Sánchez,Gisele Hansel,Elisa Nicoloso Simões Pires,Nelson Merino,Odalys Valdés,René Delgado-Hernández,Alicia Lagarto Parra,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Christianne Gazzana Salbego,Silvia Lima Costa,Diogo O. Souza,Gilberto L. Pardo-Andreu +13 more
TL;DR: The results suggest that in rats, JM-20 is a robust neuroprotective agent against ischemia/reperfusion injury with a wide therapeutic window and support the further examination of potential clinicalJM-20 use to treat acute ischemic stroke.
Journal ArticleDOI
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against Ca²⁺-induced mitochondrial impairment.
Yanier Nuñez-Figueredo,Gilberto L. Pardo-Andreu,Jeney Ramírez-Sánchez,René Delgado-Hernández,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Zeki Naal,Alexandre Pastoris Müller,Luis Valmor Cruz Portela,Diogo O. Souza +9 more
TL;DR: The antioxidant and protective effects of JM-20 against the deleterious effects of Ca(2+) observed at the mitochondrial level in this study may endow this molecule with the ability to succeed in mitochondrion-targeted strategies to combat ischemic brain damage.
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JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Yanier Nuñez-Figueredo,Jeney Ramírez-Sánchez,René Delgado-Hernández,Marlene Porto-Verdecia,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Javier Marín-Prida,Michael González-Durruthy,Sérgio Akira Uyemura,Fernando P. Rodrigues,Carlos Curti,Diogo O. Souza,Gilberto L. Pardo-Andreu +12 more
TL;DR: In rat liver mitochondria, JM-20, at low micromolar concentrations, prevented the Ca2+-induced mitochondrial permeability transition, as assessed by mitochondrial swelling, membrane potential dissipation and organelle release of the pro-apoptotic protein cytochrome c.
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Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma.
Renata Nishida Goto,Lays M. Sobral,Lucas Oliveira Sousa,Cristiana Bernadelli Garcia,Norberto Peporine Lopes,Javier Marín-Prida,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Gilberto L. Pardo-Andreu,Carlos Curti,Andréia Machado Leopoldino +10 more
TL;DR: VdiE‐2N induces HNSCC cell death in vitro through mitochondria‐mediated apoptotic pathways and dampens tumor growth in vivo, thus supporting a potential anti‐cancer effect.
Journal ArticleDOI
JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain.
Jeney Ramírez-Sánchez,Elisa Nicoloso Simões Pires,André Meneghetti,Gisele Hansel,Yanier Nuñez-Figueredo,Gilberto L. Pardo-Andreu,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,René Delgado-Hernández,Christianne Gazzana Salbego,Diogo O. Souza +10 more
TL;DR: The results reinforce the pharmacological potential of JM-20 as neuroprotective agent and provide important evidences about its molecular and cellular targets in this model of cerebral ischemia.