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Yan Xu
Researcher at Indiana University
Publications - 104
Citations - 8384
Yan Xu is an academic researcher from Indiana University. The author has contributed to research in topics: Lysophosphatidic acid & Cancer. The author has an hindex of 46, co-authored 92 publications receiving 7623 citations. Previous affiliations of Yan Xu include Cleveland Clinic Lerner College of Medicine & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal
Kirsten Lauber,Erwin Bohn,Stefan M Kröber,Yi Jin Xiao,Sibylle G. Blumenthal,Ralph K. Lindemann,P. Marini,Carolin A. Wiedig,Anke Zobywalski,Shairaz Baksh,Yan Xu,Ingo B. Autenrieth,Klaus Schulze-Osthoff,Claus Belka,Gernot Stuhler,Sebastian Wesselborg +15 more
TL;DR: Evidence is presented that apoptotic cells secrete chemotactic factor(s) that stimulate the attraction of monocytic cells and primary macrophages and that lysophosphatidylcholine was released from apoptotic Cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A(2).
Journal ArticleDOI
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.
Andrew M. Tager,Peter LaCamera,Barry S. Shea,Gabriele S. V. Campanella,Moisés Selman,Zhenwen Zhao,Vasiliy V. Polosukhin,John C. Wain,Banu A. Karimi-Shah,Nancy D. Kim,William K. Hart,Annie Pardo,Timothy S. Blackwell,Yan Xu,Jerold Chun,Andrew D. Luster +15 more
TL;DR: It is shown that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from fibrosis and mortality in this model.
Journal ArticleDOI
Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers
Yan Xu,Zhongzhou Shen,Donald W. Wiper,Minzhi Wu,Richard E. Morton,Paul Elson,Alexander W. Kennedy,Jerome L. Belinson,Maurie Markman,Graham Casey +9 more
TL;DR: Findings suggest plasma LPA levels may represent a potential biomarker for ovarian cancer and other gynecologic cancers, however, these findings are preliminary and require confirmation in larger studies.
Journal Article
Lysophospholipids are potential biomarkers of ovarian cancer.
Rebecca Sutphen,Yan Xu,George D. Wilbanks,James V. Fiorica,Edward C. Grendys,James P. LaPolla,Hector Arango,Hoffman Ms,Martin A. Martino,Katie Wakeley,David Griffin,Rafael W Blanco,Alan B. Cantor,Yijin Xiao,Jeffrey P. Krischer +14 more
TL;DR: LPA, LPI, LPC, and S1P appear useful as diagnostic and prognostic biomarkers of ovarian cancer.
Journal ArticleDOI
Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A
TL;DR: It is shown that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein–coupled receptor whose genetic ablation results in the development of autoimmunity.