Y
Yan Xu
Researcher at Peking University
Publications - 7
Citations - 474
Yan Xu is an academic researcher from Peking University. The author has contributed to research in topics: Lewis lung carcinoma & Curcumin. The author has an hindex of 7, co-authored 7 publications receiving 412 citations. Previous affiliations of Yan Xu include Boston Children's Hospital.
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Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage
TL;DR: Curcumin has the potential for use as an autophagic-related antioxidant for prevention and treatment of oxidative stress, and a novel role for curcumin in inducing a beneficial form of autophagy in HUVECs is suggested, which may be a potential multitargeted therapeutic avenue for the treatment of antioxidant-related cardiovascular diseases.
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Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells.
TL;DR: It is concluded that Rg3 effectively suppresses migration of PC-3M cells by down-regulating AQP1 expression through p38 MAPK pathway and some transcription factors acting on the AQP 1 promoter.
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Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer
Yan Xu,Jingjie Zhang,Jing Han,Xueyang Pan,Yajun Cao,Yajun Cao,Hao Guo,Yan Pan,Yu An,Xue-Jun Li +9 more
TL;DR: The results suggest that neutrophil elastase and α1‐antitrypsin play important roles in modulating lung tumor proliferation in inflammatory microenvironment and curcumin inhibits neutrophIL elastases‐induced tumor proliferation via upregulating α1-antitypsin expression in vitro and in vivo.
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Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes.
Lu Tie,Hong-Qin Yang,Yu An,Shao-Qiang Liu,Jing Han,Yan Xu,Min Hu,Wei-Dong Li,Alex F. Chen,Zhi-Bin Lin,Xuejun Li +10 more
TL;DR: Gl-PS rescued the delayed wound healing and improved wound angiogenesis in STZ-induced type 1 diabetic mice, at least in part, by suppression of cutaneous MnSOD nitration, p66Shc and mitochondrial oxidative stress.
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Opposite angiogenic outcome of curcumin against ischemia and Lewis lung cancer models: in silico, in vitro and in vivo studies.
TL;DR: Curcumin had the promise as a new treatment modality for both ischemic conditions and lung cancer simultaneously in the clinic through regulation of the HIF1α/mTOR/VEGF/VEGFR cascade oppositely.