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Yan Yang
Researcher at University of Texas Medical Branch
Publications - 8
Citations - 575
Yan Yang is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: RNA & Viral replication. The author has an hindex of 8, co-authored 8 publications receiving 542 citations.
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Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
TL;DR: It is shown that hepatitis A virus ablates type 1 IFN responses by targeting the 3ABC precursor of its 3Cpro cysteine protease to mitochondria where it colocalizes with and cleaves MAVS, thereby disrupting activation of IRF3 through the MDA5 pathway.
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Sequence requirements for viral RNA replication and VPg uridylylation directed by the internal cis-acting replication element (cre) of human rhinovirus type 14
Yan Yang,Rene Rijnbrand,Kevin L. Mcknight,Eckard Wimmer,Aniko V. Paul,Annette Martin,Annette Martin,Stanley M. Lemon +7 more
TL;DR: A direct, positive correlation between the capacity of mutated cres to support RNA replication and their ability to function as template in an in vitro VPg uridylylation reaction is found, suggesting that these functions are intimately linked.
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Genetic evidence for an interaction between a picornaviral cis-acting RNA replication element and 3CD protein.
TL;DR: It is shown that the poliovirus cre is unable to support HRV-14 RNA replication, and a model in which 3CD or its derivatives 3Cpro and 3Dpol interact directly with the stem of the cre during uridylylation of VPg is supported.
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A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of Picornavirus
Jeffrey K. Stone,Rene Rijnbrand,David A. Stein,Yinghong Ma,Yan Yang,Patrick L. Iversen,Raul Andino +6 more
TL;DR: Results suggest that EnteroX may have broad therapeutic potential against entero- and rhinovirus, and particularly against picornavirus type 14.
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A chimeric GB virus B with 5′ nontranslated RNA sequence from hepatitis C virus causes hepatitis in tamarins†
Rene Rijnbrand,Yan Yang,Lucy Beales,Francis Bodola,Kathryn Goettge,Lisette Cohen,Robert E. Lanford,Stanley M. Lemon,Annette Martin,Annette Martin +9 more
TL;DR: Novel chimeric flaviviruses offer opportunities for new insights into HCV replication mechanisms, while potentially facilitating the evaluation of candidate therapeutics in vivo, and appears to contain virus‐specific replication signals that interact with other sites within the viral genome or with viral proteins.