Y
Yang Cao
Researcher at University of Michigan
Publications - 11
Citations - 2022
Yang Cao is an academic researcher from University of Michigan. The author has contributed to research in topics: Autophagy & Autophagosome. The author has an hindex of 10, co-authored 11 publications receiving 1858 citations. Previous affiliations of Yang Cao include Princeton University & Life Sciences Institute.
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Journal ArticleDOI
Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy
TL;DR: It is found that YIL146C/ECM37 is essential for mitophagy and this autophagy-related (ATG) gene is designated as ATG32, and the Atg32 protein localizes on mitochondria and confers selectivity for mitochondrial sequestration as a cargo.
Journal ArticleDOI
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
Yang Cao,Daniel J. Klionsky +1 more
TL;DR: The current knowledge of Atg6/Beclin 1 in different model organisms and its unique function in the cell are summarized, suggesting that it plays a central role in coordinating the cytoprotective function of autophagy and in opposing the cellular death process of apoptosis.
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The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
Wei Lien Yen,Takahiro Shintani,Usha Nair,Yang Cao,Brian Richardson,Zhijian Li,Frederick M. Hughson,Misuzu Baba,Daniel J. Klionsky +8 more
TL;DR: COG subunits localize to the phagophore assembly site where they interact with autophagy proteins and are required for double-membrane Cvt vesicle and autophagosome formation.
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A role for Atg8–PE deconjugation in autophagosome biogenesis
Usha Nair,Wei Lien Yen,Muriel Mari,Yang Cao,Zhiping Xie,Misuzu Baba,Fulvio Reggiori,Daniel J. Klionsky +7 more
TL;DR: It is demonstrated that Atg8 deconjugation is an important step required to facilitate multiple events during macroautophagy, including the assembly of Atg9-containing tubulovesicular clusters into phagophores/autophagosomes, and the disassembly of PAS-associated Atg components.
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Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.
TL;DR: It is found that Atg18 and Atg21 facilitate the recruitment of Atg8–PE to the site of autophagosome formation and protect it from premature cleavage by Atg4, which represents a key aspect of post-translational autophagy regulation.