Yang Sun

TL;DR: The frontal cortex genome-wide transcriptomes in depression rats under CRS suggested that the antidepressant effect of acupuncture is effective and has a multitarget characteristic, which may be related to amino acid metabolism and inflammatory pathways, especially the Toll-like receptor signaling pathway, TNF signaling pathways, and NF-kappa B signaling pathway.

TL;DR: The antidepressant effect of acupuncture might be mediated by regulating the DNA methylation and histone modifications of brain-derived neurotrophic factor, which may represent novel biomaker for detection of depression and monitoring severity and antidepressive effects.

TL;DR: Either MA or EA combined SSRIs treatment could improve symptoms and quality of life for patients with moderate to severe depression.

TL;DR: Acupuncture reversed the upregulation of gene sets that were related to inflammatory response, innate immunity and immune response (including toll-like receptor signalling pathway and NOD like receptors signalling pathway), which might be critical for the pathogenesis of depression and provide evidence for the antidepressive effects of acupuncture.

TL;DR: Electroacupuncture pretreatment implied that EA pretreatment could alleviate depression through modulating MAPK signaling pathway and the role of EA on dopaminergic synapse signaling pathways needs to be further explored.