Jun Lu

TL;DR: It is suggested that acupuncture has antidepressant-like effects, and its mechanism of action appears to involve the inhibition of proinflammatory cytokines.

TL;DR: The results showed that CUMS rats exhibited the reduction in behavioral activities, whereas acupuncture stimulation at acupoints Baihui and Neiguan reversed the behavioral deficit and one potential way, by which acupuncture had antidepressant-like effect, might be mediated by activating the ERK-CREB pathway in the brain.

TL;DR: Findings showed that the antidepressant-like effect of acupuncture might be mediated by inhibition of inflammatory mediators via modulation of NF-κB in the brain regions, which was alleviated by acupuncture treatment.

TL;DR: It is found that EA stimulation at specific locations ameliorated the behavioral responses of CUMS, which included reduced locomotion, decreased sucrose intake and weight loss, and the behavioral and biochemical responses to EA were attenuated with administration of ERK inhibitor, suggesting that EA improves depression-like symptoms in stressed rats, in part, by activation ofERK signaling.

TL;DR: The antidepressant effect of acupuncture might be mediated by regulating the DNA methylation and histone modifications of brain-derived neurotrophic factor, which may represent novel biomaker for detection of depression and monitoring severity and antidepressive effects.