Journal ArticleDOI
Genome-wide transcriptome analysis of hippocampus in rats indicated that TLR/NLR signaling pathway was involved in the pathogenisis of depressive disorder induced by chronic restraint stress.
Yu Wang,Huili Jiang,Hong Meng,Jun Lu,Jing Li,Xu-hui Zhang,Xinjing Yang,Bingcong Zhao,Yang Sun,Tuya Bao +9 more
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TLDR
Acupuncture reversed the upregulation of gene sets that were related to inflammatory response, innate immunity and immune response (including toll-like receptor signalling pathway and NOD like receptors signalling pathway), which might be critical for the pathogenesis of depression and provide evidence for the antidepressive effects of acupuncture.About:
This article is published in Brain Research Bulletin.The article was published on 2017-09-01. It has received 21 citations till now. The article focuses on the topics: Innate immune system & Immune system.read more
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Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture
Yuanjia Zheng,Jiang He,Lili Guo,Lin Yao,Xiaorong Zheng,Zhihua Yang,Yucen Xia,Xiaoli Wu,Su Yang,Xu Nenggui,Yongjun Chen +10 more
TL;DR: Results suggest that EA at GV20 and GV29 ameliorates depression-related manifestations by regulating the expression of multiple genes.
Journal ArticleDOI
Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases.
TL;DR: Signal transduction pathways through which acupuncture treats nervous system diseases are reviewed, finding that acupuncture affects synaptic plasticity, causes an increase in neurotrophic factors, and results in neuroprotection, cell proliferation, antiapoptosis, antioxidant activity, anti-inflammation, and maintenance of the blood-brain barrier.
Journal ArticleDOI
Validity of chronic restraint stress for modeling anhedonic-like behavior in rodents: a systematic review and meta-analysis
Ye Mao,Yong-Cheng Xu,Xia Yuan +2 more
TL;DR: A meta-analysis of studies that used the CRS paradigm to evaluate anhedonic-like behavior in rodents was focused on a core symptom of depression (anhedonia) as the main endpoint of the model and identified species-dependent susceptibility to restraint stress.
Journal ArticleDOI
Factor analysis of electroacupuncture and selective serotonin reuptake inhibitors for major depressive disorder: an 8-week controlled clinical trial
Xinjing Yang,Xinjing Yang,Weijun Gong,Xuehong Ma,Sihan Wang,Xueqin Wang,Tianwei Guo,Zhuo Guo,Yang Sun,Jing Li,Bingcong Zhao,Ya Tu +11 more
TL;DR: Electroacupuncture appeared to result in greater symptom improvement than SSRI treatment with respect to anxiety/somatisation and feelings of despair, but as a potential therapy for MDD, the results of this secondary analysis should be interpreted cautiously.
Journal ArticleDOI
The Role of Potassium Channels in Chronic Stress-Induced Brain Injury
Jianhui Ren,Jiquan Guo,Shuguang Zhu,Qiyou Wang,Ruiping Gao,Chunhe Zhao,Chuyu Feng,Cuiying Qin,Zhenfeng He,Changyun Qin,Zhanle Wang,Linquan Zang +11 more
TL;DR: It is suggested that potassium channel function is disrupted in CSBI, and thatassium channel regulators may function as anti-CSBI drugs.
References
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Yoav Benjamini,Yosef Hochberg +1 more
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.
TL;DR: EdgeR as mentioned in this paper is a Bioconductor software package for examining differential expression of replicated count data, which uses an overdispersed Poisson model to account for both biological and technical variability and empirical Bayes methods are used to moderate the degree of overdispersion across transcripts, improving the reliability of inference.
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TopHat: discovering splice junctions with RNA-Seq
TL;DR: The TopHat pipeline is much faster than previous systems, mapping nearly 2.2 million reads per CPU hour, which is sufficient to process an entire RNA-Seq experiment in less than a day on a standard desktop computer.