Bone grafts and biomaterials substitutes for bone defect repair: A review.

3D bioactive composite scaffolds for bone tissue engineering.

Advancing biomaterials of human origin for tissue engineering

Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective.

https://web.iitd.ac.in/~sghosh08/publications/actabio2015.pdf

Silk fibroin as biomaterial for bone tissue engineering

Increased use of reconstruction procedures in orthopedics, due to trauma, tumor, deformity, degeneration and an aging population, has caused a blossom, not only in surgical advancement, but also in the development of bone implants. Traditional synthetic porous scaffolds are made of metals, polymers, ceramics or even composite biomaterials, in which the design does not consider the native structure and properties of cells and natural tissues. Thus, these synthetic scaffolds often poorly integrate with the cells and surrounding host tissue, thereby resulting in unsatisfactory surgical outcomes due to poor corrosion and wear, mechanical mismatch, unamiable surface environment, and other unfavorable properties. Musculoskeletal tissue reconstruction is the ultimate objective in orthopedic surgery. This objective can be achieved by (i) prosthesis or fixation device implantation, and (ii) tissue engineered bone scaffolds. These devices focus on the design of implants, regardless of the choice of new biomaterials. Indeed, metallic materials, e.g. 316L stainless steel, titanium alloys and cobalt chromium alloys, are predominantly used in bone surgeries, especially in the load-bearing zone of prostheses. The engineered scaffolds take biodegradability, cell biology, biomolecules and material mechanical properties into account, in which these features are ideally suited for bone tissue repair and regeneration. Therefore, the design of the scaffold is extremely important to the success of clinical outcomes in musculoskeletal surgeries. The ideal scaffolds should mimic the natural extracellular matrix (ECM) as much as possible, since the ECM found in natural tissues supports cell attachment, proliferation, and differentiation, indicating that scaffolds should consist of appropriate biochemistry and nano/micro-scale surface topographies, in order to formulate favorable binding sites to actively regulate and control cell and tissue behavior, while interacting with host cells. In addition, scaffolds should also possess a similar macro structure to what is found in natural bone. This feature may provide space for the growth of cells and new tissues, as well as for the carriers of growth factors. Another important concern is the mechanical properties of scaffolds. It has been reported that the mechanical features can significantly influence the osteointegration between implants and surrounding tissues, as well as cell behaviors. Since natural bone exhibits super-elastic biomechanical properties with a Young's modulus value in the range of 1–27 GPa, the ideal scaffolds should mimic strength, stiffness and mechanical behavior, so as to avoid possible post-operation stress shielding effects, which induce bone resorption and consequent implant failure. In addition, the rate of degradation and the by-products of biodegradable materials are also critical in the role of bone regeneration. Indeed, the mechanical integrity of a scaffold will be significantly reduced if the degradation rate is rapid, thereby resulting in a pre-matured collapse of the scaffold before the tissue is regenerated. Another concern is that the by-products upon degradation may alter the tissue microenvironment and then challenge the biocompatibility of the scaffold and the subsequent tissue repair. Therefore, these two factors should be carefully considered when designing new biomaterials for tissue regeneration. To address the aforementioned questions, an overview of the design of ideal biomimetic porous scaffolds is presented in this paper. Hence, a number of original engineering processes and techniques, including the production of a hierarchical structure on both the macro- and nano-scales, the adjustment of biomechanical properties through structural alignment and chemical components, the control of the biodegradability of the scaffold and its by-products, the change of biomimetic surface properties by altering interfacial chemistry, and micro- and nano-topographies will be discussed. In general, the concepts and techniques mentioned above provide insights into designing superior biomimetic scaffolds for bone tissue engineering.

Biomimetic porous scaffolds for bone tissue engineering

The invention provides a rapid photodynamic sterilization chitosan-black phosphorus composite hydrogel dressing and a preparation method thereof. The preparation method includes the steps: S1 dispersing BP (black phosphorus) crystal powder in deionized water, leading in argon serving as protecting gas, performing ultrasonic treatment under an ice-bath condition and finally performing centrifugation to obtain upper nanometer black phosphorus sheet water solution for standby application; S2 preparing chitosan hydrogel; S3 preparing chitosan-black phosphorus composite hydrogel. In the preparation process, harmful gas is avoided, and the preparation method is economical, environmentally friendly, simple, less in equipment investment, low in resource consumption and less in implementation difficulty. The antibacterial rate of the composite hydrogel illuminated for ten minutes can reach 99% or more, and the composite hydrogel is good in biocompatibility.

Chitosan-black phosphorus composite hydrogel and preparation method thereof

The invention discloses a preparation method of a graphene oxide/nanosilver coating wrapped by collagen film The preparation method includes steps: loading nanosilver on the surface of graphene oxide; subjecting a titanium sheet to alkali-heat treatment; aminating the titanium sheet; loading a graphene oxide/nanosilver composite material on the surface of the titanium sheet; covering the surface of the titanium sheet with the collagen film after compositing is finished Graphene oxide, nanosilver and collagen are organically combined, nanosilver is uniformly loaded on a graphene oxide sheet in a size of several nanometers through graphene oxide, and the defect that collagen is prone to degradation is improved A hybrid coating material prepared by the method has antibacterial activity and high biocompatibility, and the hybrid coating is irradiated by visible light to generate active oxygen to kill bacteria

Preparation method of graphene oxide/nanosilver coating wrapped by collagen film

An antimicrobial nano-particle preparation method using a metal-organic framework as a biocarrier for packing a medicine comprises the following steps: S1, correspondingly mixing ferric chloridehexahydrate andterephthalic acid with N, N-dimethylformamide,and arranging into an inner tank of a Teflon reaction kettle; S2, arranging the inner tank of the reaction kettle into an oven,increasing the temperature,and then cooling; S3, centrifuging the substance cooled in step 2,collecting the precipitate,then performing washing and suction filtration on the product,drying in vacuum,and grinding to obtain metal-organic framework nano-particles; S4, mixing the metal-organic framework nano-particles and vancomycin,dissolving the mixture in deionized water,and then absorbing and loading medicine; and S5, filtering the substance obtained in step S5,washing,performing suction filtration,and drying in vacuum to obtain the medicine-packed metal-organic frameworknano-particle composite The method has the advantages of being capable of absorbing various different macromolecular and micromolecular medicines to form a double-functional metal-organic framework medicine loading system, and being simple in preparation process, green and environment-friendly

Yang Xianjin

Papers

Biomimetic porous scaffolds for bone tissue engineering

Chitosan-black phosphorus composite hydrogel and preparation method thereof

Preparation method of graphene oxide/nanosilver coating wrapped by collagen film

Antimicrobial nano-particle preparation method using metal-organic framework as biocarrier for packing medicine