Y
Yang Xu
Researcher at Second Military Medical University
Publications - 19
Citations - 558
Yang Xu is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Protein kinase B & Signal transduction. The author has an hindex of 11, co-authored 18 publications receiving 443 citations.
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Journal ArticleDOI
Anti-tumor activities of matrine and oxymatrine: literature review
TL;DR: This review summarizes the recent investigations regarding the anti-cancer activities and possible molecular targets of MT and OMT for cancer prevention and treatment in order to provide clues and references for further study.
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Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.
Zhangxiao Peng,Yan Wang,Jianhui Fan,Xuejing Lin,Chunying Liu,Yang Xu,Weidan Ji,Chao Yan,Changqing Su +8 more
TL;DR: The findings indicated that VOSL and CD could induce breast cancer cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 signaling pathways and may be novel effective candidates for breast cancer treatment.
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Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways
TL;DR: The findings indicated that WM130 could inhibit cell proliferation, invasion, migration and induced apoptosis in HCC cells by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways and may be a novel effective candidate for HCC treatment.
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Hypoxia-Induced Mesenchymal Stromal Cells Exhibit an Enhanced Therapeutic Effect on Radiation-Induced Lung Injury in Mice due to an Increased Proliferation Potential and Enhanced Antioxidant Ability.
Bailong Li,Cheng Li,Mo Zhu,Youjun Zhang,Jicong Du,Yang Xu,Bin Liu,Fu Gao,Hu Liu,Jianming Cai,Yanyong Yang +10 more
TL;DR: Investigating whether persistent and adaptive hypoxia treatment of bmMSCs prior to their transplantation in injured mice enhanced survival and improved curative effects in RILI foundHypoxia enhances the therapeutic effect of mesenchymal stromal cells on radiation-induced lung injury by promoting MSC proliferation and improving their antioxidant ability, mediated by HIF-1α.
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An Artificially Designed Interfering lncRNA Expressed by Oncolytic Adenovirus Competitively Consumes OncomiRs to Exert Antitumor Efficacy in Hepatocellular Carcinoma.
TL;DR: An artificially designed interfering long noncoding RNA (lncRNAi), which contains the sequences that can complementarily bind to multiple OncomiRs and is expressed by cancer-selectively replicating adenovirus, achieves the targeted anti-HCC efficacy.