Yang Xuan

TL;DR: A comprehensive whole-brain atlas defining the monosynaptic inputs onto forebrain-projecting serotonergic neurons of dorsal versus median raphe based on a genetically restricted transsynaptic retrograde tracing strategy is generated.

TL;DR: A framework to automatically annotate, analyze, visualize and easily share whole-brain data at cellular resolution, based on a scale-invariant and interactive mouse brain reference atlas is developed and applied to define the organization and cocaine-induced activity of corticostriatal circuits.

TL;DR: Brain-wide maps of the afferent input to four distinct cell types in the medial prefrontal cortex are generated to reveal the structural architecture that underlies the mPFC’s functions.

TL;DR: It is found that the LHb-projecting LHA Vglut2 neurons encode negative valence and rapidly develop a prediction signal for negative events, establishing the glutamatergic LHA-LHb circuit as a critical node in value processing.

TL;DR: It is shown in female Drosophila that germline stem cell division rate progressively declines with age, which is accompanied by reduced decapentaplegic niche signaling pathway activation within GSCs, and suggested that niche functional decay may be an important mechanism for stem cell aging and system failure.