Y
Yang Zhang
Researcher at Peking University
Publications - 50
Citations - 1712
Yang Zhang is an academic researcher from Peking University. The author has contributed to research in topics: Population & Helicobacter pylori. The author has an hindex of 18, co-authored 49 publications receiving 1267 citations. Previous affiliations of Yang Zhang include Technische Universität München.
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Journal ArticleDOI
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
Hongxing Zhang,Yun Zhai,Zhibin Hu,Chen Wu,Ji Qian,Wei Hua Jia,Fuchao Ma,Wenfeng Huang,Lixia Yu,Wei Yue,Zhifu Wang,Peiyao Li,Yang Zhang,Renxiang Liang,Zhongliang Wei,Ying Cui,Weimin Xie,Mi Cai,Xinsen Yu,Yunfei Yuan,Xia Xia,Xiumei Zhang,Hao Yang,Wei Qiu,Jingmin Yang,Feng Gong,Minshan Chen,Hongbing Shen,Dongxin Lin,Yi Xin Zeng,Fuchu He,Gangqiao Zhou +31 more
TL;DR: The findings provide evidence that the 1p36.22 locus confers susceptibility to HBV-related HCC, and suggest that KIF1B-, UBE4B- or PGD-related pathways might be involved in the pathogenesis of this malignancy.
Journal ArticleDOI
Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer
Yang Guo,Yang Zhang,Markus Gerhard,Juan-Juan Gao,Raquel Mejías-Luque,Lian Zhang,Michael Vieth,Jun-Ling Ma,Monther Bajbouj,Stepan Suchanek,Wei-Dong Liu,Kurt Ulm,Michael Quante,Zhe-Xuan Li,Tong Zhou,Roland M. Schmid,Meinhard Classen,Wen-Qing Li,Wei-Cheng You,Kai-Feng Pan +19 more
TL;DR: It is revealed that the dysbiotic microbiota in H. pylori positive mucosa was associated with advanced gastric lesions and could be reversed by eradication and shows beneficial effects on gut microbiota.
Journal ArticleDOI
A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication
Kai-Feng Pan,Lian Zhang,Markus Gerhard,Jun-Ling Ma,Wei-Dong Liu,Kurt Ulm,Jian-xi Wang,Lei Zhang,Yang Zhang,Monther Bajbouj,Lan-fu Zhang,Ming Li,Michael Vieth,Rui-yong Liu,Michael Quante,Le-hua Wang,Stepan Suchanek,Tong Zhou,Wei-xiang Guan,Roland M. Schmid,Meinhard Classen,Wei-Cheng You +21 more
TL;DR: This large community-based intervention trial to eradicate H. pylori is feasible and acceptable, and a distinct evaluation of factors influencing eradication that should be generally considered for future eradication therapies is lead to.
Journal ArticleDOI
Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial
Wen-Qing Li,Jing-Yu Zhang,Jun-Ling Ma,Zhe-Xuan Li,Lian Zhang,Yang Zhang,Yang Guo,Tong Zhou,Ji-You Li,Lin Shen,Wei-dong Liu,Zhongxiang Han,William J. Blot,Mitchell H. Gail,Kai-Feng Pan,Wei-Cheng You +15 more
TL;DR: H pylori treatment for two weeks and vitamin or garlic supplementation for seven years were associated with a statistically significant reduced risk of death due to gastric cancer for more than 22 years and vitamin supplementation was also associated withA statistically significantly reduced incidence of Gastric cancer.
Journal ArticleDOI
Genetic Variants in Cyclooxygenase-2: Expression and Risk of Gastric Cancer and Its Precursors in a Chinese Population
Fen Liu,Kai-Feng Pan,Xuemei Zhang,Yang Zhang,Lian Zhang,Jun-Ling Ma,Cai-Xuan Dong,Lin Shen,Ji-You Li,Dajun Deng,Dongxin Lin,Wei-Cheng You +11 more
TL;DR: It is suggested that COX-2 polymorphisms may play an important role, at least in part, in developing GC in this high-risk population of China.