Yangguang Zhu

TL;DR: The novel ternary copper(II) complex was shown to bind DNA by intercalation and cleave pBR322 DNA in the presence of ascorbate, and exhibited potent cytotoxic effects against human leukemia cell line HL-60 and human stomach cancer cell line SGC-7901 with inhibition rates of over 90%, however, less pronounced effects were observed.

TL;DR: This review will highlight the most recent progress in the area of artificial metallonucleases employing an oxidative mechanism, focusing on the development of methodologies for cleavage detection, understanding of the factors governing the Cleavage efficacy and selectivity, and design strategies for the achievement of high cleavage efficacy.

TL;DR: Interestingly, the additional copper center to the meta-dicopper motif in complex 3 decreased the cleavage efficacy of meta-tetra-(2-pyridylmethyl)-p-xylylenediamine motif incomplex 1, although it is able to cleave DNA to the linear form at higher [Cu2+] concentrations.

TL;DR: A highly water soluble 3:2 complex of copper(II) and 2,4,6-tris(di-2-pyridylamine)-1,3,5-triazine (TDAT) has been synthesized and structurally characterized and can bind to DNA through electrostatic attraction and cleave efficiently the supercoiled pBR322 DNA into its nicked and linear forms.

TL;DR: This study provides a less common example for the phosphodiesterase model in which the metal-bound alkoxide is the nucleophile and the dizinc complex formed in situ in anhydrous DMSO exhibits a similar ability to cleave BNPP.