Y
Yanzhi Wang
Researcher at Tsinghua University
Publications - 6
Citations - 98
Yanzhi Wang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 2 publications receiving 50 citations.
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Journal ArticleDOI
LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2
Meijian Liao,Weijie Liao,Naihan Xu,Bing Li,Fuhai Liu,Shikuan Zhang,Yanzhi Wang,Songmao Wang,Yuanchang Zhu,Deheng Chen,Weidong Xie,Yuyang Jiang,Liu Cao,Burton B. Yang,Yaou Zhang +14 more
TL;DR: EPB41L4A-AS1 functions as a repressor of the Warburg effect and plays important roles in metabolic reprogramming of cancer.
Journal ArticleDOI
Persistent high glucose induced EPB41L4A‐AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non‐histones
Wei-Lin Liao,Naihan Xu,Haowei Zhang,Weifang Liao,Yanzhi Wang,Song-Zi Wang,Shikuan Zhang,Yuyang Jiang,Weidong Xie,Yaou Zhang +9 more
TL;DR: Since a weaker glucose uptake ability is one of the major clinical features of T2DM, the inhibition of EPB41L4A‐AS1 expression seems to be a potentially effective strategy for drug development in T2 DM treatment.
Posted ContentDOI
Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP.
Tingpeng Yang,Yanzhi Wang,Weijie Liao,Shikuan Zhang,Songmao Wang,Naihan Xu,Weidong Xie,Cheng Luo,Yangyang Wang,Ziqiang Wang,Yaou Zhang +10 more
TL;DR: Down-regulation of EPB41L4A-AS1 not only disturbs NAD+ biosynthesis but also affects ATP production, so the high demand of brain for NAD+ and ATP can not be met and promotes the development of brain aging and neurodegenerative diseases.
Journal ArticleDOI
BESST: a novel LncRNA knockout strategy with less genome perturbance
Shikuan Zhang,Yue Chen,Kunzhe Dong,Yiwan Zhao,Yanzhi Wang,Song-Zi Wang,Chen Qu,Naihan Xu,Weidong Xie,Chunyu Zeng,Qing Rex Lyu,Yaou Zhang +11 more
TL;DR: In this article , the authors introduced a novel lncRNA knockout strategy, BESST, by deleting the genomic DNA fragment from the branch point to the 3′ splicing site in the last intron of the target lncRN.
Journal ArticleDOI
A Whole Exon Screening-Based Score Model Predicts Prognosis and Immune Checkpoint Inhibitor Therapy Effects in Low-Grade Glioma
Cheng Luo,Song-Zi Wang,Wenjie Shan,Wei-Lin Liao,Shikuan Zhang,Yanzhi Wang,Qilei Xin,Tingpeng Yang,Shaoliang Hu,Weidong Xie,Naihan Xu,Yaou Zhang +11 more
TL;DR: An accurate prediction model based on seven genes based on METTL7B, one of the risk genes, can predict the prognosis of patients and identify the potential benefits of immune checkpoint inhibitors (ICI) therapy for LGG.