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Yao-Chang Chen
Researcher at National Taiwan University
Publications - 115
Citations - 7690
Yao-Chang Chen is an academic researcher from National Taiwan University. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 44, co-authored 109 publications receiving 7237 citations. Previous affiliations of Yao-Chang Chen include National Health Research Institutes.
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Journal ArticleDOI
The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells.
Tsai Hua Chung,Si Han Wu,Ming Yao,Chen Wen Lu,Yu Shen Lin,Yann Hung,Chung-Yuan Mou,Yao-Chang Chen,Yao-Chang Chen,Dong Ming Huang +9 more
TL;DR: The results show that MSNs uptake by hMSCs can be regulated by a threshold of positive surface charge but also imply that the modulation of surface charge on MSN uptake is specific to cell type.
Journal ArticleDOI
Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling.
Chen Wen Lu,Yann Hung,Jong-Kai Hsiao,Ming Yao,Tsai Hua Chung,Yu Shen Lin,Si Han Wu,Szu Chun Hsu,Hon-Man Liu,Chung-Yuan Mou,Chung Shi Yang,Dong Ming Huang,Yao-Chang Chen +12 more
TL;DR: This is the first report that hMSCs can be efficiently labeled with MRI contrast nanoparticles and can be monitored in vitro and in vivo with a clinical 1.5-T MRI imager under low incubation concentration of iron oxide, short incubation time, and low detection cell numbers at the same time.
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AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.
Jih-Luh Tang,Hsin-An Hou,Chien-Yuan Chen,Chieh-Yu Liu,Wen-Chien Chou,Mei-Hsuan Tseng,Chi-Fei Huang,Fen-Yu Lee,Ming-Chih Liu,Ming Yao,Shang-Yi Huang,Bor-Sheng Ko,Szu-Chun Hsu,Shang-Ju Wu,Woei Tsay,Yao-Chang Chen,Liang-In Lin,Hwei-Fang Tien +17 more
TL;DR: It is demonstrated that RUNX1 mutation was an independent poor prognostic factor for overall survival and associated with distinct biologic and clinical characteristics and poor prognosis in patients with de novo AML.
Journal ArticleDOI
The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles.
Dong-Ming Huang,Jong-Kai Hsiao,Ying-Chun Chen,Li-Ying Chien,Ming Yao,Yin-Kai Chen,Bor-Sheng Ko,Szu-Chun Hsu,Lin-Ai Tai,Hui-Ying Cheng,Shih-Wei Wang,Chung-Shi Yang,Yao-Chang Chen +12 more
TL;DR: Ferucarbotran, an ionic SPIO, is not toxic to human mesenchymal stem cells (hMSCs) under the conditions of these experiments but instead increases cell growth, which may be mediated by the free iron released from lysosomal degradation.
Journal ArticleDOI
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics.
Wen-Chien Chou,Sheng-Chieh Chou,Chieh-Yu Liu,Chien-Yuan Chen,Hsin-An Hou,Yuan-Yeh Kuo,Ming-Cheng Lee,Bor-Sheng Ko,Jih-Luh Tang,Ming Yao,Woei Tsay,Shang-Ju Wu,Shang-Yi Huang,Szu-Chun Hsu,Yao-Chang Chen,Yi-Chang Chang,Yi-Yi Kuo,Kuan-Ting Kuo,Fen-Yu Lee,Ming-Chi Liu,Chia-Wen Liu,Mei-Hsuan Tseng,Chi-Fei Huang,Hwei-Fang Tien +23 more
TL;DR: TET2 mutation is associated with poor prognosis in AML patients with intermediate-risk cytogenetics, especially when it is combined with other adverse molecular markers.