Y
Yassin M. Nissan
Researcher at Cairo University
Publications - 39
Citations - 675
Yassin M. Nissan is an academic researcher from Cairo University. The author has contributed to research in topics: Biological activity & Pyrazole. The author has an hindex of 14, co-authored 36 publications receiving 505 citations. Previous affiliations of Yassin M. Nissan include King Saud University.
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Journal ArticleDOI
New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES
Ghaneya S. Hassan,Doaa E. Abdel Rahman,Esraa A. Abdelmajeed,Rana H. Refaey,M. Alaraby Salem,Yassin M. Nissan +5 more
TL;DR: New pyrazole derivatives 2-5 showed good inhibitory activity at a nanomolar level and most compounds exhibited selectivity towards COX-2 inhibition, while all the tested compounds exhibited potent inhibitory effect on the production of PGE2, in addition to their inhibition of COx-2 enzyme.
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Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties
TL;DR: Among the tested derivatives, compounds 16, 18 and 20-24 showed potent activity as inhibitors for the tumor associated transmembrane isoforms (hCA IX and XII) in the nanomolar and subnanomolar range, with high selectivity.
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Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking
Mostafa M. Ghorab,Mansour S. Alsaid,Mohamed S. A. El-Gaby,Mahmoud M. Elaasser,Yassin M. Nissan +4 more
TL;DR: Novel compounds were obtained with good anticancer and antibacterial activity especially fluorinated pyridine derivative 4a and molecular docking study suggest good activity as mitogen activated protein kinase-2 inhibitor.
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Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling
Mostafa M. Ghorab,Mariangela Ceruso,Mansour S. Alsaid,Yassin M. Nissan,Reem K. Arafa,Claudiu T. Supuran +5 more
TL;DR: Novel pyrrole and pyrrolopyrimidine scaffold-based sulfonamides were designed and synthesized and their binding modes were comparable with that of AZA.
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Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.
TL;DR: A new series of pyrazolone-pyridazine conjugates 3 and 4a-l were synthesized and characterized by spectroscopic means and elemental analyses and showed good analgesic and anti-inflammatory activities with lower ulcer index than the reference drug.