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Yasuhiro Hamada
Researcher at University of Tokushima
Publications - 59
Citations - 1723
Yasuhiro Hamada is an academic researcher from University of Tokushima. The author has contributed to research in topics: Bone remodeling & Oxidative stress. The author has an hindex of 19, co-authored 59 publications receiving 1555 citations. Previous affiliations of Yasuhiro Hamada include Kobe University.
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Journal ArticleDOI
Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
Hirotaka Komaba,Shunsuke Goto,Hideki Fujii,Yasuhiro Hamada,Akira Kobayashi,Koji Shibuya,Yoshihiro Tominaga,Naoki Otsuki,Ken-ichi Nibu,Kimie Nakagawa,Naoko Tsugawa,Toshio Okano,Riko Kitazawa,Masafumi Fukagawa +13 more
TL;DR: The results suggest that the depressed expression of the Klotho-FGFR1 complex in hyperplastic glands underlies the pathogenesis of SHPT and its resistance to extremely high FGF23 levels in uremic patients.
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Role of oxidative stress in diabetic bone disorder.
TL;DR: The impact of diabetes-induced oxidative stress in the development of diabetic bone disorder is focused on and it is demonstrated that both streptozotocin-induced diabetic mice and spontaneously diabetic Torii rats, an animal model of type 2 diabetes, have low-turnover osteopenia associated with increased oxidative stress.
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Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: A possible role of oxidative stress
TL;DR: It is demonstrated that streptozotocin-induced diabetic mice exhibit low-turnover osteopenia associated with increased oxidative stress, and intensified immunostaining of an oxidative stress marker in bone tissue including the osteoblasts of diabetic mice.
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Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells
Bing-Fen Liu,Satoshi Miyata,Yushi Hirota,Satomi Higo,Hiroyuki Miyazaki,Michiru Fukunaga,Yasuhiro Hamada,Shigemitsu Ueyama,Osamu Muramoto,Atsuko Uriuhara,Masato Kasuga +10 more
TL;DR: A potential role for MG is suggested in glomerular injury through p38 MAPK activation under diabetic conditions and may serve as a novel insight into the therapeutic strategies for diabetic nephropathy.
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The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE−/−) mice
Ognen Ivanovski,Igor G. Nikolov,Igor G. Nikolov,Nobuhiko Joki,Axelle Caudrillier,Olivier Phan,Romuald Mentaverri,Julien Maizel,Yasuhiro Hamada,Thao Nguyen-Khoa,Masafumi Fukagawa,Said Kamel,Bernard Lacour,Tilman B. Drüeke,Ziad A. Massy +14 more
TL;DR: The calcimimetic R-568 delayed the progression of both aortic calcification and atherosclerosis in uremic apoE(-/-) mice, mediated via a better control of hyperparathyroidism including serum Ca and phosphorus.