Ye Deng

TL;DR: Two new benzophenones, morintrifolins A and B, together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of Morinda citrifolia roots, showing quinone reductase (QR)- inducing activity in Hepa lclc7 cells.

TL;DR: Using in vitro hydroxyl radical-scavenging and quinone reductase-inducing assays, bioactivity-guided fractionation of an ethyl acetate-soluble extract of the fruits of the botanical dietary supplement, black chokeberry, led to the isolation of 27 compounds, including a new depside, ethyl 2-[(3,4- dihydroxybenzoyloxy)-4,6-dihydroxyphenyl].

TL;DR: A new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride, showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leish maniasis model.

TL;DR: Elaeocarpucin C, produced by partial synthesis from 16α,23α-epoxy-3β,20β-dihydroxy-10αH,23βH-cucurbit-5,24-dien-11-one, was found to be inactive when evaluated in an in vivo hollow fiber assay using three different cancer cell types (dose range 0.5-10 mg/kg/day, i.p.).

TL;DR: A phytochemical investigation of the leaves of Vitex quinata (Lour.) F.N. Williams (Verbenaceae) led to the isolation of a new δ-truxinate derivative and a new phytonoic acid derivative, together with 12 known compounds.