Y
Yen-Chou Chen
Researcher at Taipei Medical University
Publications - 29
Citations - 1571
Yen-Chou Chen is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Apoptosis & Caspase 3. The author has an hindex of 20, co-authored 29 publications receiving 1445 citations. Previous affiliations of Yen-Chou Chen include Taipei Medical University Hospital.
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Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages.
TL;DR: Induction of HO-1 protein may participate in the protective mechanism of QE on oxidative stress (H(2)O(2))-induced apoptosis, and reduction of intracellular ROS production and mitochondria dysfunction with blocking apoptotic events were involved.
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Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1.
TL;DR: Evidence is provided on the role of HO-1 in the inhibition of LPS-induced NO production by flavonoids by dose-dependent stimulation of flavonoid- and hemin-treated cells and enhanced their inhibitory effects on L PS-induced nitric oxide production and iNOS protein expression.
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Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.
Yen-Chou Chen,Shing-Chuan Shen,Woan-Ruoh Lee,Hui Yi Lin,Ching Huai Ko,Chun-Ming Shih,Ling-Ling Yang +6 more
TL;DR: Molecular evidence is provided to demonstrate that wogonin and fisetin had effective cytotoxic effects through apoptosis induction in hepatocellular carcinoma cells SK-HEP-1; activation of caspase 3 cascade, induction of p53 protein and alternative expression of p21Waf/Cip-1 protein were involved.
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Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE2 activation
Wen Ta Chiu,Shing-Chuan Shen,Jyh-Ming Chow,Cheng Wei Lin,Ling Tin Shia,Yen-Chou Chen,Yen-Chou Chen +6 more
TL;DR: Data from the pharmacological studies using specific chemical inhibitors showed that activation of protein kinase C and extracellular signal-regulated kinases (ERKs) was involved in TPA-induced migration/invasion, COX-2 protein expression, and MMP-9 activation.
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Antioxidant activities of trypsin inhibitor, a 33 KDa root storage protein of sweet potato (Ipomoea batatas (L.) Lam cv. Tainong 57).
TL;DR: It is suggested that 33 kDa TI, one of the sweet potato root storage proteins, may play a role as an antioxidant in roots and may be beneficial to health when it is consumed.