Yen-Chywan Liaw

TL;DR: The three-dimensional molecular structures of the complexes between an interesting antitumor drug, nogalamycin, and two DNA hexamers, d[CGT(pS)ACG] and d[m5C GT( pS)Am5CG], were determined at high resolution by X-ray diffraction analyses to suggest that nogAlamycin may prefer GC sequences embedded in a stretch of AT sequences.

TL;DR: A cage‐like model consisting of a tetrameric c‐(GpGp) aggregate in which a large cavity is generated to afford a binding site for certain planar intercalators (‘guests’) is proposed.

TL;DR: The left-handed Z structures of two hexamers containing ribose and arabinose residues have been solved by X-ray diffraction analysis at 1.5-A resolution and the potential biological roles of the modified Z-DNA containing anticancer nucleoside araC and of Z-RNA are discussed.

TL;DR: The three-dimensional structure of the 2:1 adduct between MAR70 and d(CGTnACG) suggests that placing a reactive functional group at the N3' amino position of daunorubicin might be a fruitful route for designing anticancer drugs.

TL;DR: The interactions between a novel antitumor drug nogalamycin with the self-complementary DNA hexamer d(CGTACG) have been studied by 500 MHz two dimensional proton nuclear magnetic resonance spectroscopy.