J
Jacques H. van Boom
Researcher at Leiden University
Publications - 340
Citations - 12460
Jacques H. van Boom is an academic researcher from Leiden University. The author has contributed to research in topics: DNA & Oligonucleotide. The author has an hindex of 52, co-authored 340 publications receiving 12174 citations. Previous affiliations of Jacques H. van Boom include Technical University of Berlin.
Papers
More filters
Journal ArticleDOI
Prevalence of ras gene mutations in human colorectal cancers
Johannes L. Bos,Matty Verlaan de Vries,Alex J. van der Eb,Eric R. Fearon,Bert Vogelstein,Stanley R. Hamilton,Jacques H. van Boom +6 more
TL;DR: A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
Journal ArticleDOI
Protein-primed RNA synthesis by purified poliovirus RNA polymerase
TL;DR: The identification of the internal ribosomal-entry site, which allows the entry of ribosomes into viral mRNA independently of the 5′ mRNA end, has been solved and it is shown that VPg can be uridylylated by the poliovirus RNA polymerase 3Dpol.
Journal ArticleDOI
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.
Johannes L. Bos,Deniz Toksoz,Christopher J. Marshall,Matty Verlaan de Vries,G. H. Veeneman,Alex J. van der Eb,Jacques H. van Boom,Johannes W.G. Janssen,Ada C. M. Steenvoorden +8 more
TL;DR: DNAs from four out of five patients with acute myeloid leukaemia tested by an in vivo selection assay in nude mice using transfected mouse NIH 3T3 cells were found to contain an activated N-ras oncogene.
Journal ArticleDOI
Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg
TL;DR: A small RNA hairpin has been discovered in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation of VPg.
Journal ArticleDOI
The conformation of neurotensin bound to its G protein-coupled receptor
Sorin Luca,Jim White,Awinder K. Sohal,Dmitri V. Filippov,Jacques H. van Boom,Reinhard Grisshammer,Marc Baldus +6 more
TL;DR: The conformation of a high-affinity peptide agonist (neurotensin, NT) bound to its GPCR NTS-1, determined by direct structural methods is presented, providing a viable structural template for further pharmacological investigations.