D
Dewey Kim
Researcher at Broad Institute
Publications - 23
Citations - 504
Dewey Kim is an academic researcher from Broad Institute. The author has contributed to research in topics: Metastatic breast cancer & Breast cancer. The author has an hindex of 8, co-authored 17 publications receiving 197 citations. Previous affiliations of Dewey Kim include Harvard University.
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Journal ArticleDOI
The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor–positive metastatic breast cancer
Seth A. Wander,Ofir Cohen,Ofir Cohen,Xueqian Gong,Gabriela N. Johnson,Gabriela N. Johnson,Jorge E. Buendia-Buendia,Jorge E. Buendia-Buendia,Maxwell R. Lloyd,Dewey Kim,Dewey Kim,Flora Luo,Pingping Mao,Karla Helvie,Kailey J. Kowalski,Kailey J. Kowalski,Utthara Nayar,Adrienne G. Waks,Stephen Parsons,Ricardo Martinez,Lacey M. Litchfield,Xiang S. Ye,Chunping Yu,Valerie M. Jansen,John R. Stille,Patricia S Smith,Gerard J. Oakley,Quincy Chu,Gerald Batist,Melissa E. Hughes,Jill D. Kremer,Levi A. Garraway,Eric P. Winer,Sara M. Tolaney,Nan Lin,Sean Buchanan,Nikhil Wagle +36 more
TL;DR: Whole exome sequencing of 59 tumors with CDK4/6i exposure revealed multiple candidate resistance mechanisms including RB1 loss, activating alterations in AKT1, RAS, AURKA, CCNE2, ERBB2, and FGFR2, which may define therapeutic opportunities in patients.
Journal ArticleDOI
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.
Corrie A. Painter,Esha Jain,Esha Jain,Brett N. Tomson,Michael Dunphy,Rachel Stoddard,Beena Thomas,Alyssa L. Damon,Shahrayz Shah,Dewey Kim,Dewey Kim,Jorge Gómez Tejeda Zañudo,Jorge Gómez Tejeda Zañudo,Jason L. Hornick,Yen-Lin Chen,Priscilla Merriam,Chandrajit P. Raut,Chandrajit P. Raut,George D. Demetri,Brian A. Van Tine,Eric S. Lander,Todd R. Golub,Todd R. Golub,Nikhil Wagle +23 more
TL;DR: A framework of patient-partnered research allows patients with angiosarcoma to share their samples and clinical records securely to accelerate molecular characterization of tumors and identification of therapeutic approaches, demonstrating that empowering patients to directly participate in research can overcome barriers in rare diseases and can enable discoveries.
Posted ContentDOI
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research
Corrie A. Painter,Esha Jain,Esha Jain,Brett N. Tomson,Michael Dunphy,Rachel Stoddard,Beena Thomas,Alyssa L. Damon,Shahrayz Shah,Dewey Kim,Dewey Kim,Jorge Gómez Tejeda Zañudo,Jorge Gómez Tejeda Zañudo,Jason L. Hornick,Yen-Lin Chen,Priscilla Merriam,Chandrajit P. Raut,Chandrajit P. Raut,George D. Demetri,Brian A. Van Tine,Eric S. Lander,Todd R. Golub,Todd R. Golub,Nikhil Wagle +23 more
TL;DR: A patient-partnered research approach using online engagement to discover the etiology and potential therapies for angiosarcoma patients demonstrates that empowering patients to directly participate in research can overcome barriers in rare diseases and enable biological and clinical discoveries.
Posted ContentDOI
The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer
Seth A. Wander,Ofir Cohen,Ofir Cohen,Xueqian Gong,Gabriela N. Johnson,Gabriela N. Johnson,Jorge E. Buendia-Buendia,Jorge E. Buendia-Buendia,Maxwell R. Lloyd,Dewey Kim,Dewey Kim,Flora Luo,Pingping Mao,Karla Helvie,Kailey J. Kowalski,Kailey J. Kowalski,Utthara Nayar,Adrienne G. Waks,Stephen Parsons,Ricardo Martinez,Lacey M. Litchfield,Xiang S. Ye,Chunping Yu,Valerie M. Jansen,John R. Stille,Patricia S Smith,Gerard J. Oakley,Quincy Chu,Gerald Batist,Melissa E. Hughes,Jill D. Kremer,Levi A. Garraway,Eric P. Winer,Sara M. Tolaney,Nan Lin,Sean Buchanan,Nikhil Wagle +36 more
TL;DR: Eight distinct mechanisms of resistance to CDK4/6 inhibitors present in 80% of resistant tumors profiled have critical implications related to the potential utility of precision-based approaches to overcome resistance in many patients with HR+ MBC.
Journal ArticleDOI
The Metastatic Breast Cancer (MBC) project: Accelerating translational research through direct patient engagement.
Nikhil Wagle,Corrie A. Painter,Elana Anastasio,Michael Dunphy,Mary McGillicuddy,Dewey Kim,Esha Jain,Jorge E. Buendia-Buendia,Ofir Cohen,Erik H. Knelson,Jamie Holloway,Shawn F. Johnson,Katie Larkin,Viktor A. Adalsteinsson,Gavin Ha,Samuel S. Freeman,Greg Gydush,Sarah C. Reed,Eric S. Lander,Todd R. Golub +19 more
TL;DR: Clinical and genomic data are used to generate genomic landscapes in pt subgroups and to identify mechanisms of response and resistance to therapies to accelerate research.