Y
Yenamandra S. Prabhakar
Researcher at Central Drug Research Institute
Publications - 70
Citations - 1191
Yenamandra S. Prabhakar is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Quantitative structure–activity relationship & Docking (molecular). The author has an hindex of 20, co-authored 69 publications receiving 1100 citations. Previous affiliations of Yenamandra S. Prabhakar include Council of Scientific and Industrial Research & Academy of Scientific and Innovative Research.
Papers
More filters
Journal ArticleDOI
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT inhibitors.
TL;DR: An attempt in correlating the derived physicochemical properties with the HIV-RT inhibitory activity resulted in some statistically significant QSAR models with good predictive ability.
Journal ArticleDOI
CP‐MLR/PLS Directed Structure‐Activity Modeling of the HIV‐1 RT Inhibitory Activity of 2,3‐Diaryl‐1,3‐thiazolidin‐4‐ones
TL;DR: The study suggests that thiazolidinones with 3-(pyridin-2-yl) moiety provide scope for further substituent variation to modulate the HIV-1 RT inhibitory activity.
Journal ArticleDOI
A Combinatorial Approach to the Variable Selection in Multiple Linear Regression: Analysis of Selwood et al. Data Set – A Case Study
TL;DR: A combinatorial protocol is introduced here to interface it with the multiple linear regression (MLR) for variable selection and it is demonstrated that the proposed method should be able to offer solutions to data sets with 50 to 60 descriptors in reasonable time frame.
Journal ArticleDOI
C-3 Alkyl/Arylalkyl-2,3-dideoxy Hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation, and QSAR Study
Mohammad Saquib,Manish K. Gupta,Ram Sagar,Yenamandra S. Prabhakar,Arun K. Shaw,Rishi Kumar,Prakas R. Maulik,Anil N. Gaikwad,Sudhir Sinha,Anil Srivastava,Vinita Chaturvedi,and Ranjana Srivastava,Brahm S. Srivastava +12 more
TL;DR: The study indicates that the compounds attaining the conformational space of 5c and reflecting some symmetry, minimum eccentricity, and closely placed geometric and electronegativity centers therein are favorable for activity.
Journal ArticleDOI
CoMFA and CoMSIA studies on thiazolidin-4-one as anti-HIV-1 agents.
TL;DR: The results provide insight for predictive and diagnostic aspects of this class of HIV-1 RT inhibitors for better activity and 3D contour maps generated from these models provide the regions in space where interactive fields may influence the activity.