Y
Yi Cai
Researcher at Baylor College of Medicine
Publications - 18
Citations - 1703
Yi Cai is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 15, co-authored 18 publications receiving 1625 citations. Previous affiliations of Yi Cai include Texas A&M University System & United States Department of Veterans Affairs.
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Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer
TL;DR: Both the isoforms of TMPRSS2/ERG fusions expressed and expression level may affect prostate cancer progression, and in this group, higher expression levels of fusion mRNA were present in cancers with early prostate-specific antigen recurrence.
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Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.
TL;DR: It is shown that a conserved protein, translationally controlled tumour protein (TCTP), is an essential new component of the TSC–Rheb pathway and a potential therapeutic target for TSC disease.
Journal Article
Identification and Characterization of Mouse Metastasis-suppressor KiSS1 and Its G-Protein-coupled Receptor
TL;DR: Mouse homologues of the KiSS1 peptide and its G-protein-coupled receptor are identified and the signaling pathways mediated by the activation of the kiSS1 receptor are characterized, which suggests direct coupling of the Kaizen-mediate PLC-Ca2+ signaling pathway.
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Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts.
Jianghua Wang,Yi Cai,Yi Cai,Wendong Yu,Chengxi Ren,Chengxi Ren,David M. Spencer,Michael Ittmann,Michael Ittmann +8 more
TL;DR: The results indicate that TMPRSS2/ERG fusion isoforms have variable biological activities promoting tumor initiation and progression and are consistent with previous clinical observations indicating that certain TMPR SS2-ERG fusionisoforms are significantly correlated with more aggressive disease.
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Steroid Receptor Coactivator-3/AIB1 Promotes Cell Migration and Invasiveness through Focal Adhesion Turnover and Matrix Metalloproteinase Expression
Jun Yan,Halime Erdem,Rile Li,Yi Cai,Gustavo Ayala,Michael Ittmann,Li Yuan Yu-Lee,Sophia Y. Tsai,Ming-Jer Tsai +8 more
TL;DR: It is reported that the elevated SRC-3/AIB1 expression is significantly correlated with human prostate cancer seminal vesicle invasion and lymph node metastasis, and this data suggest that SRC/Aib1 plays an essential role in prostate cancer cell invasion and metastasis.