Yi Jonathan Zhang

TL;DR: Investigation of whether the systemic administration of HER2-specific chimeric antigen receptor (CAR)–modified virus-specific T cells (VSTs) is safe and whether these cells have antiglioblastoma activity found them to be well tolerated.

TL;DR: Gene transfer allows the reliable generation of Her2-specific T cells from GBM patients, which have potent antitumor activity against autologous HER2-positive tumors including their putative stem cells, Hence, the adoptive transfer of HER1-redirected T cells may be a promising immunotherapeutic approach for GBM.

TL;DR: Both HER2/IL-13Rα2-bispecific T cell products offset antigen escape, producing enhanced effector activity in vitro immunoassays and in an orthotopic xenogeneic murine model.

TL;DR: In this nonrandomized sample of 90 MCA aneurysms treated with endovascular coiling or neurosurgical clipping, a similar clinical outcome was observed based on the modified Rankin scale and angiographic occlusion.

TL;DR: ETV is a good option in the management of secondary communicating H CP, normal pressure HCP, and replacing malfunctioning ventriculoperitoneal shunts and the indications of ETV as a first-line treatment in communicating HCP needs further study.