S
Suzanne Zein-Eldin Powell
Researcher at Houston Methodist Hospital
Publications - 132
Citations - 4476
Suzanne Zein-Eldin Powell is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Graduate medical education & Neuropathology. The author has an hindex of 32, co-authored 129 publications receiving 3651 citations. Previous affiliations of Suzanne Zein-Eldin Powell include Cornell University & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial
Nabil Ahmed,Nabil Ahmed,Vita S. Brawley,Vita S. Brawley,Meenakshi Hegde,Meenakshi Hegde,Kevin Bielamowicz,Mamta Kalra,Daniel Landi,Daniel Landi,Catherine Robertson,Tara Gray,Oumar Diouf,Amanda Wakefield,Amanda Wakefield,Alexia Ghazi,Claudia Gerken,Claudia Gerken,Zhongzhen Yi,Zhongzhen Yi,Aidin Ashoori,Meng Fen Wu,Hao Liu,Cliona M. Rooney,Gianpietro Dotti,Adrian P. Gee,Adrian P. Gee,Jack Su,Yvonne Kew,David S. Baskin,Yi Jonathan Zhang,Pamela New,Bambi Grilley,Bambi Grilley,Milica Stojakovic,Milica Stojakovic,John Hicks,Suzanne Zein-Eldin Powell,Malcolm K. Brenner,Helen E. Heslop,Robert G. Grossman,Winfried S. Wels,Stephen Gottschalk +42 more
TL;DR: Investigation of whether the systemic administration of HER2-specific chimeric antigen receptor (CAR)–modified virus-specific T cells (VSTs) is safe and whether these cells have antiglioblastoma activity found them to be well tolerated.
Journal ArticleDOI
HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors
Nabil Ahmed,Vita S. Salsman,Yvonne Kew,Donald R. Shaffer,Suzanne Zein-Eldin Powell,Yi Jonathan Zhang,Robert G. Grossman,Helen E. Heslop,Stephen Gottschalk +8 more
TL;DR: Gene transfer allows the reliable generation of Her2-specific T cells from GBM patients, which have potent antitumor activity against autologous HER2-positive tumors including their putative stem cells, Hence, the adoptive transfer of HER1-redirected T cells may be a promising immunotherapeutic approach for GBM.
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Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
Jenny S. Henkel,David R. Beers,Shixiang Wen,Andreana L. Rivera,Karen M. Toennis,Joan E. Appel,Weihua Zhao,Dan H. Moore,Suzanne Zein-Eldin Powell,Stanley H. Appel +9 more
TL;DR: It is suggested that Tregs and Th2 lymphocytes influence disease progression rates, and early reduced FoxP3 levels could be used to identify rapidly progressing patients.
Journal ArticleDOI
T cells redirected to EphA2 for the immunotherapy of glioblastoma.
Kevin Chow,Swati Naik,Sunitha Kakarla,Vita S. Brawley,Donald R. Shaffer,Zhongzhen Yi,Nino Rainusso,Meng Fen Wu,Hao Liu,Yvonne Kew,Robert G. Grossman,Suzanne Zein-Eldin Powell,Dean A. Lee,Nabil Ahmed,Stephen Gottschalk +14 more
TL;DR: Adoptive transfer of EphA2-specific T cells resulted in the regression of glioma xenografts in severe combined immunodeficiency mice and a significant survival advantage in comparison to untreated mice and mice treated with nontransduced T cells.
Journal ArticleDOI
Expanding the spectrum of neuronal pathology in multiple system atrophy
Matthew D. Cykowski,Elizabeth A. Coon,Suzanne Zein-Eldin Powell,Sarah M. Jenkins,Eduardo E. Benarroch,Phillip A. Low,Ann M. Schmeichel,Joseph E. Parisi +7 more
TL;DR: The identification of widespread neuronal inclusions in the majority of patients, not only in typical disease-associated regions, but also within anterior cingulate cortex, amygdala, entorhinal cortex, basal forebrain and hypothalamus, suggests that in addition to glial inclusions, neuronal pathology plays an important role in the developmental and progression of multiple system atrophy.