Y
Yi Lu
Researcher at Fudan University
Publications - 315
Citations - 8048
Yi Lu is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Cataract surgery. The author has an hindex of 40, co-authored 260 publications receiving 5471 citations. Previous affiliations of Yi Lu include Purdue University & Tongji University.
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Adapting liposomes for oral drug delivery
TL;DR: This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes and suggests that modulating the compositions of the lipid bilayers and adding polymers or ligands can be greatly improved for oral drug delivery.
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Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt.
TL;DR: In vivo measurements of pharmacokinetics and bioavailability demonstrated higher rates of fenofibrate absorption from both SPC/SDC and SPC/, indicating that liposomes containing bile salts may be used to enhance oral bioavailability of poorly water-soluble drugs.
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Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose.
TL;DR: The hypothesis of insulin absorption as intact liposomes as well as SGC-liposomes showed higher oral bioavailability and the hypoglycemic effect was size-dependent with the highest at 150 nm or 400 nm and was proportionally correlated to the administered dose.
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Biotinylated liposomes as potential carriers for the oral delivery of insulin.
TL;DR: Biotinylated liposomes were utilized as carriers of insulin for local delivery, demonstrating the feasibility of this approach in a rat model and providing a proof of concept that BLPs can be used as potential carriers for the oral delivery of insulin.
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Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool.
TL;DR: The ACQ-based bioimaging strategy is emerging as a promising tool to achieve more accurateBioimaging of drug nanocarriers with a focus on improving the accuracy of bioim imaging of nanoparticles.