Showing papers in "European Journal of Pharmaceutics and Biopharmaceutics in 2012"

TL;DR: Within the past 20 years, a considerable amount of work has been published on chitosan and its potential use in drug delivery systems.

TL;DR: Electrospun scaffolds are highly versatile systems for the incorporation of various drugs and allow for significant variation with regard to scaffold material, spatial design, and surface modification.

TL;DR: The results indicate that the nanofibrillar cellulose is a highly promising new material for sustained release drug delivery applications.

TL;DR: The results showed that the quality of granules and tablets can be optimized by adjusting specific process variables during a granulation process using a continuous twin screw granulator.

TL;DR: In this article, the authors discuss passive and active targeting of nanoparticles and several classes of pH-responsive nanoparticles, and discuss active and passive targeting strategies for nanoparticles that provide controlled release at a specific site.

TL;DR: Improved stability in co-amorphous SVS-GPZ mixtures was concluded that this was attributable to the molecular level mixing of SVS with GPZ upon milling, and GPZ is acting as an anti-plasticizer in these mixtures.

TL;DR: While the complexity and predictive value of the BBB model is the highest, for the screening of NCEs to determine whether they are efflux substrates or not, the VB-Caco-2 and the MDCK-MDR1 models may provide a simple and inexpensive tool.

TL;DR: The hypothesis of insulin absorption as intact liposomes as well as SGC-liposomes showed higher oral bioavailability and the hypoglycemic effect was size-dependent with the highest at 150 nm or 400 nm and was proportionally correlated to the administered dose.

TL;DR: PH-sensitive polymeric nanoparticles are promising for oral drug delivery, especially for peptide/protein drugs and poorly water-soluble medicines, and most carriers used are enteric-coating materials and their safety has been approved.

TL;DR: Taste sensing technology demonstrated taste improvement for both polymers by correlating the data obtained for the placebo polymers and the pure APIs alone and the best masking effect was observed for VA64 at 30% PMOL loading.

TL;DR: The selection of carrier is an important factor in the development of solidSNEDDS, since the carriers had significant effects on the crystalline properties, dissolution and oral bioavailability of flurbiprofen and on the formation of solid SNEDDS.

TL;DR: In this review, it will be demonstrated how properties and dysfunctions of mitochondrialria are generating a need for the development of mitochondria specific therapies, intracellular targets of mitochondrial diseases, strategies to utilize mitochondrial specificities and targeting approaches will be discussed.

TL;DR: The best (drug-Cd)-loaded NLC system, formulated into a xanthan hydrogel, exhibited drug permeation properties clearly better than those of the plain drug suspension or the plainDrug- loaded NLC, in virtue of the simultaneous exploitation of the solubilizing effect of cyclodextrin and the penetration enhancer properties of NLC.

TL;DR: The use of cSLN increased the cellular uptake of fluorescent dsRNA in human epithelial carcinoma KB cells, with PcSLN complexed to fluorescence-labeled ds RNA promoting the greatest uptake.

TL;DR: A predictive risk-based approach was set up in order to account for the uncertainties and correlations found in the process and in the derived critical quality attributes such as the yield, the moisture content, the inhalable fraction of powder, the compressibility index, and the Hausner ratio.

TL;DR: The dissolution rates of the quercetin nanosuspensions fabricated by these three methods enhanced compared to the coarse quercetus, and both the particle size and saturation solubility values were enhanced.

TL;DR: For the first time, implementation of permeation in precipitation assays is demonstrated to be critical to predict the impact of supersaturation, precipitation, and precipitation inhibition on the absorption of poorly soluble drugs.

TL;DR: The results showed that microencapsulation decreased membrane permeation of CO by at least 50%.

TL;DR: The data indicate that PTX loaded FLPNPs are a promising nano-sized drug formulation for cancer therapy.

TL;DR: It is concluded that β-CN shows promise to be useful for target-activated oral delivery of hydrophobic chemotherapeutics in the treatment of gastric carcinoma, one of the leading causes of cancer mortality worldwide.

TL;DR: In vivo the effects of a novel CsA topical aqueous formulation based on nanosized polymeric micelles as drug carriers is investigated, which has the capacity to overcome the ocular surface barriers and is clearly an effective and well-tolerated alternative to the systemic treatment for the prevention of corneal graft rejection.

TL;DR: In this paper, the authors performed comparative tape stripping experiments in which the skin penetration of curcumin and fluorescein sodium from conventional microemulsions and hydrogels was investigated.

TL;DR: The aim of this work was to study the potential of pegylated poly(anhydride) nanoparticles as carriers for the oral delivery of paclitaxel (PTX), characterised for its low aqueous solubility and to act as a substrate of the P-glycoprotein and cytochrome P450.

TL;DR: The enhanced permanency in blood of A-PL suggests the use of these nanosystems as suitable passive targeted carriers for parasitic infections; this strong effect of formulation is added up to the mechanism of action of artemisinin which acts in the erythrocyte cycle stage of human host as a blood schizonticide.

TL;DR: Topical application of ethosomal tacrolimus displayed the lowest ear swelling in BALB/c mice model induced by repeated topical application of 2,4-dinitrofluorobenzene compared to traditional liposomes and commercial ointment and effectively impeded accumulation of mast cells in the ear of the mice, suggesting efficient suppression for the allergic reactions.

TL;DR: The highest fine particle fraction (FPF), that is the amount of active pharmaceutical substance, delivered to the deep lung, is achieved when using rough, spherical carrier particles, while the FPF decreases when irregular shaped particles are used.

TL;DR: The results demonstrated the effectiveness of the proposed jointed use of drug cyclodextrin complexation and chitosan-Ca-alginate microsphere vectorization, as well as the usefulness of the multivariate approach for the preparation of colon-targeted celecoxib microspheres with optimized properties.

TL;DR: In vitro data show that the skin application of paclitaxel-loaded ethosomes® improved the permeation of pac litaxel in a stratum corneum-epidermis membrane model and increased its anti-proliferative activity in a squamous cell carcinoma model as compared to the free drug.

TL;DR: Drug nanocrystals were invented at the start of the 1990s, based on the dates of the first patent filings by Nanosystems (now Élan), RTP Canada (now SkyePharma Canada) and DDS Drug Delivery Services GmbH (IP now owned by Skye Pharma).

TL;DR: Overall a two- to fivefold enhancement in bioavailability in comparison with control confers the potential of proliposomes as suitable carriers for improved oral delivery of zaleplon.