Yi Sun

TL;DR: It is concluded that there are important differences in the neural substrates mediating induction and emergence that support the concept that emergence depends, in part, on recruitment and stabilization of wake-active regions of brain.

TL;DR: It is demonstrated that such a barrier separates wakeful and anesthetized states for multiple anesthetics in both flies and mice, and argued that it contributes to the hysteresis observed when the brain transitions between conscious and unconscious states.

TL;DR: Evidence is provided that Rab3a-mediated synaptic transmission is involved in circadian period and sleep homeostasis, and a point mutation in the conserved amino acid (Asp77Gly) within the GTP-binding domain of this protein in earlybird mutants resulted in significantly reduced levels of Rab3A protein.

TL;DR: REM sleep rebound after exposure to volatile anesthetics suggests that these volatileAnesthetics do not fully substitute for natural sleep, compared with the published actions of propofol for which no REM sleep rebound occurred.

TL;DR: Findings implicate DGKD disruption by the t(X;2)(p11.2;q37)dn in the observed phenotype and support a more general role for diacylglycerol kinase delta in the etiology of seizures.